The recent demonstration of the effectiveness of low-dose aspirin administered from the first trimester in the prevention of preeclampsia will probably lead to establishing and radicating the "inverted pyramid" screening model for preeclampsia. Such a multiparametric approach for the screening of preeclampsia in the first trimester, albeit highly sensitive in identifying early-onset disease, is poor at screening the forms of preeclampsia occurring close to term. Late-onset preeclampsia is 3 to 6 times more common than early-onset preeclampsia and currently represents the major determinant of maternal morbidity related to hypertensive disorders of the pregnancy. On this ground, we discuss our idea to construct a second "screening checkpoint" in the third trimester with the aim of reassessing the risk of preeclampsia of those women who screened negative in the first trimester. If implemented, the sequential screening model we propose would convert the "inverted pyramid model" into an "arrow model" for the antenatal care of preeclampsia.

Antenatal Care of Preeclampsia: From the Inverted Pyramid to the Arrow Model? / Ghi, Tullio; Dall'Asta, Andrea; Valensise, Herbert. - In: FETAL DIAGNOSIS AND THERAPY. - ISSN 1015-3837. - 44:2(2018), pp. 81-84. [10.1159/000490047]

Antenatal Care of Preeclampsia: From the Inverted Pyramid to the Arrow Model?

Ghi, Tullio
Writing – Original Draft Preparation
;
Dall'Asta, Andrea
Membro del Collaboration Group
;
2018

Abstract

The recent demonstration of the effectiveness of low-dose aspirin administered from the first trimester in the prevention of preeclampsia will probably lead to establishing and radicating the "inverted pyramid" screening model for preeclampsia. Such a multiparametric approach for the screening of preeclampsia in the first trimester, albeit highly sensitive in identifying early-onset disease, is poor at screening the forms of preeclampsia occurring close to term. Late-onset preeclampsia is 3 to 6 times more common than early-onset preeclampsia and currently represents the major determinant of maternal morbidity related to hypertensive disorders of the pregnancy. On this ground, we discuss our idea to construct a second "screening checkpoint" in the third trimester with the aim of reassessing the risk of preeclampsia of those women who screened negative in the first trimester. If implemented, the sequential screening model we propose would convert the "inverted pyramid model" into an "arrow model" for the antenatal care of preeclampsia.
Antenatal Care of Preeclampsia: From the Inverted Pyramid to the Arrow Model? / Ghi, Tullio; Dall'Asta, Andrea; Valensise, Herbert. - In: FETAL DIAGNOSIS AND THERAPY. - ISSN 1015-3837. - 44:2(2018), pp. 81-84. [10.1159/000490047]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2849515
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