Vitamin D plays a pivotal role in the regulation of calcium-phosphorus metabolism, particularly during pediatric age when nutritional rickets and impaired bone mass acquisition may occur.Besides its historical skeletal functions, in the last years it has been demonstrated that vitamin D directly or indirectly regulates up to 1250 genes, playing so-called extraskeletal actions. Indeed, recent data suggest a possible role of vitamin D in the pathogenesis of several pathological conditions, including infectious, allergic and autoimmune diseases. Thus, vitamin D deficiency may affect not only musculoskeletal health but also a potentially wide range of acute and chronic conditions. At present, the prevalence of vitamin D deficiency is high in Italian children and adolescents, and national recommendations on vitamin D supplementation during pediatric age are lacking. An expert panel of the Italian Society of Preventive and Social Pediatrics reviewed available literature focusing on randomized controlled trials of vitamin D supplementation to provide a practical approach to vitamin D supplementation for infants, children and adolescents.

Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians / Saggese, Giuseppe; Vierucci, Francesco; Prodam, Flavia; Cardinale, Fabio; Cetin, Irene; Chiappini, Elena; De' Angelis, Gian Luigi; Massari, Maddalena; Miraglia Del Giudice, Emanuele; Miraglia Del Giudice, Michele; Peroni, Diego; Terracciano, Luigi; Agostiniani, Rino; Careddu, Domenico; Ghiglioni, Daniele Giovanni; Bona, Gianni; Di Mauro, Giuseppe; Corsello, Giovanni. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1824-7288. - 44:1(2018), p. 51. [10.1186/s13052-018-0488-7]

Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians

De' Angelis, Gian Luigi;BONA, GIANNI;
2018-01-01

Abstract

Vitamin D plays a pivotal role in the regulation of calcium-phosphorus metabolism, particularly during pediatric age when nutritional rickets and impaired bone mass acquisition may occur.Besides its historical skeletal functions, in the last years it has been demonstrated that vitamin D directly or indirectly regulates up to 1250 genes, playing so-called extraskeletal actions. Indeed, recent data suggest a possible role of vitamin D in the pathogenesis of several pathological conditions, including infectious, allergic and autoimmune diseases. Thus, vitamin D deficiency may affect not only musculoskeletal health but also a potentially wide range of acute and chronic conditions. At present, the prevalence of vitamin D deficiency is high in Italian children and adolescents, and national recommendations on vitamin D supplementation during pediatric age are lacking. An expert panel of the Italian Society of Preventive and Social Pediatrics reviewed available literature focusing on randomized controlled trials of vitamin D supplementation to provide a practical approach to vitamin D supplementation for infants, children and adolescents.
Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians / Saggese, Giuseppe; Vierucci, Francesco; Prodam, Flavia; Cardinale, Fabio; Cetin, Irene; Chiappini, Elena; De' Angelis, Gian Luigi; Massari, Maddalena; Miraglia Del Giudice, Emanuele; Miraglia Del Giudice, Michele; Peroni, Diego; Terracciano, Luigi; Agostiniani, Rino; Careddu, Domenico; Ghiglioni, Daniele Giovanni; Bona, Gianni; Di Mauro, Giuseppe; Corsello, Giovanni. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1824-7288. - 44:1(2018), p. 51. [10.1186/s13052-018-0488-7]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2847162
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