Several studies have shown an influence of cigarette smoking on serum pepsinogen group I (PGI) levels in duodenal ulcer patients and in control subjects. The elevation of PGI in smokers has just been interpreted as reflecting some degree of smoking-induced inflammation of the gastric mucosa. We have determined fasting serum PGI by radioimmunoassay in 163 healthy subjects investigated by a survey conducted on a sample population of an urban area in the North-East of Italy by means of a random selection based on the public registers of home addresses. The data reported confirmed that PGI levels are increased by smoking in a healthy population. The main contribution of this study consists in demonstrating in a non-selected population an increase of the only parameter up to date claimed to be a possible serological predictive index for ulcer disease.

[Cigarette smoking and group I pepsinogen levels. Study in a normal population] / Germanà, B; Di Mario, F; Vianello, F; Dotto, P; Faggian, D; Plebani, M; Saggioro, A; Naccarato, R. - In: GIORNALE DI CLINICA MEDICA. - ISSN 0017-0275. - 71:8-9(1990), p. 493-5.

[Cigarette smoking and group I pepsinogen levels. Study in a normal population]

Di Mario, F;
1990-01-01

Abstract

Several studies have shown an influence of cigarette smoking on serum pepsinogen group I (PGI) levels in duodenal ulcer patients and in control subjects. The elevation of PGI in smokers has just been interpreted as reflecting some degree of smoking-induced inflammation of the gastric mucosa. We have determined fasting serum PGI by radioimmunoassay in 163 healthy subjects investigated by a survey conducted on a sample population of an urban area in the North-East of Italy by means of a random selection based on the public registers of home addresses. The data reported confirmed that PGI levels are increased by smoking in a healthy population. The main contribution of this study consists in demonstrating in a non-selected population an increase of the only parameter up to date claimed to be a possible serological predictive index for ulcer disease.
1990
[Cigarette smoking and group I pepsinogen levels. Study in a normal population] / Germanà, B; Di Mario, F; Vianello, F; Dotto, P; Faggian, D; Plebani, M; Saggioro, A; Naccarato, R. - In: GIORNALE DI CLINICA MEDICA. - ISSN 0017-0275. - 71:8-9(1990), p. 493-5.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2844691
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact