The effects of Nizatidine, an H2-receptor antagonist, and Misoprostol, a PGE1 analogue, on gastric pH, pepsin, pepsinogen group I and N-acetylneuraminic acid concentration were evaluated in a group of 20 patients with duodenal ulcer. Nizatidine decreased pepsin concentration while it increased gastric pH, although not to a significant degree and left pepsinogen group I and N-acetylneuraminic acid concentration unchanged. Misoprostol did not modify gastric pH, pepsin and N-acetylneuraminic acid values but it increased pepsinogen group I levels. These data support the view that H2-receptor antagonists, especially Nizatidine, and Misoprostol do not directly affect pepsin and/or N-acetylneuraminic acid concentration.
EFFETTO DELLA NIZATIDINA E DEL MISOPROSTOL SULL'ATTIVITA PEPTICA E SUL MUCO GASTRICO SOLUTO / Grassi, S. A.; Vianello, F.; Germana, B.; Dal Santo, P.; Faggian, D.; Battaglia, G.; Plebani, M.; Di Mario, F.; Naccarato, R.. - In: MEDICINA. - ISSN 0392-6516. - 10:1(1990), pp. 29-31.
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