The effect of full-dose famotidine treatment (40 mg/nightly for six months) on mucus and peptic secretion was evaluated in 28 patients with duodenal ulcer. After one month of therapy, the drug decreased acid glycoproteins, N-acetylneuraminic acid, and pepsin and increased pepsinogen I, gastrin, and pH. Treatment for an additional six months also showed an increase in neutral glycoproteins and a decrease in pepsin, while the remaining above-mentioned parameters returned to baseline values. The effects were probably due to the presence of superficial gastritis, to gastrin increase, and to a modification in gastric volumes.
The effect of full-dose famotidine therapy on mucus and pepsin concentrations -b / Vianello, F.; Di Mario, F.; Vio, A.; Tessaro, P.; Pasqualetti, P.; Dal Santo, P. L.; Farinati, F.; Naccarato, R.. - In: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL. - ISSN 0011-393X. - 48:1(1990), pp. 91-95.
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