Background Fingolimod is an efficient and safe drug for treating relapsing-remitting multiple sclerosis (RRMS). In vivo, fingolimod is phosphorylated and binds to “sphingosine-1-phosphate”(S1P) receptors that are expressed in a wide range of cells, including lymphocytes. Under the effect of fingolimod, lymphocytes are retained in lymphoid tissues through the regulation of S1P1receptors. The aim of the present study was to assess whether the degree of lymphopenia was correlated to the positive treatment response of RRMS patients with fingolimod. Methods Data was sourced from the MSBase Registry. Patients were divided into two groups, according to the lymphocyte count on peripheral blood examination. Annualized Relapse Rate (ARR), time to first relapse and time to six-month confirmed disability progression were compared between groups. Results Group one consisted of 202 patients who reached 750 lymphocytes/mm3during treatment while the comparison group two included 101 patients who never reached less than 1000 lymphocytes/mm3in peripheral blood during the observation period. There were no differences between groups in ARR, time to first relapse or time to six-month confirmed disability progression. Conclusion The degree of lymphopenia in peripheral blood was not associated to the positive treatment response of fingolimod in RRMS patients.

Lymphocyte count in peripheral blood is not associated with the level of clinical response to treatment with fingolimod / Fragoso, Yara Dadalti; Spelman, Tim; Boz, Cavit; Alroughani, Raed; Lugaresi, Alessandra; Vucic, Steve; Butzkueven, Helmut; Terzi, Murat; Havrdova, Eva; Horakova, Dana; Granella, Franco; Olascoaga, Javier; Sánchez-Menoyo, José Luis; Pucci, Eugenio; Barnett, Michael; Brooks, Joseph Bruno B.; Haartsen, Jodi. - In: MULTIPLE SCLEROSIS AND RELATED DISORDERS. - ISSN 2211-0348. - 19(2018), pp. 105-108. [10.1016/j.msard.2017.11.018]

Lymphocyte count in peripheral blood is not associated with the level of clinical response to treatment with fingolimod

Granella, Franco;
2018

Abstract

Background Fingolimod is an efficient and safe drug for treating relapsing-remitting multiple sclerosis (RRMS). In vivo, fingolimod is phosphorylated and binds to “sphingosine-1-phosphate”(S1P) receptors that are expressed in a wide range of cells, including lymphocytes. Under the effect of fingolimod, lymphocytes are retained in lymphoid tissues through the regulation of S1P1receptors. The aim of the present study was to assess whether the degree of lymphopenia was correlated to the positive treatment response of RRMS patients with fingolimod. Methods Data was sourced from the MSBase Registry. Patients were divided into two groups, according to the lymphocyte count on peripheral blood examination. Annualized Relapse Rate (ARR), time to first relapse and time to six-month confirmed disability progression were compared between groups. Results Group one consisted of 202 patients who reached 750 lymphocytes/mm3during treatment while the comparison group two included 101 patients who never reached less than 1000 lymphocytes/mm3in peripheral blood during the observation period. There were no differences between groups in ARR, time to first relapse or time to six-month confirmed disability progression. Conclusion The degree of lymphopenia in peripheral blood was not associated to the positive treatment response of fingolimod in RRMS patients.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2844481
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