This experimental and clinical study examined the relationship between oesophageal damage and optimal pH of refuxate, and whether 24‐h pH monitoring at optimal pH could discriminate the severity of oesophagitis. The rabbit oesophagus was perfused in vivo with pepsin and hydrochloric acid solutions of difering pH for 60 min. Maximal oesophageal damage coincided with peptic solutions at pH 1.5–2.5. Fifty‐nine patients with proven gastro‐oesophageal reflux disorders were tested for manometric features of the lower oesophageal sphincter (Pressure, overall length and abdominal length) and oesophageal exposure to different pH levels. They were classified into four groups according to the endoscopically demonstrated severity of oesophagitis. Supine exposure at the optimal pH level for pepsin activity (pH 1.5–2.5) and overall sphincter length were found to discriminate the severity of oesophagitis reliably in 75 per cent of cases. Copyright © 1992 British Journal of Surgery Society Ltd.

Oesophagitis and pH of refluxate: an experimental and clinical study / Zaninotto, G.; di Mario, F.; Costantini, M.; Baffa, R.; Germanà, B.; Santo, P. L. Dal; Rugge, M.; Bolzan, M.; Naccarato, R.; Ancona, E.. - In: BRITISH JOURNAL OF SURGERY. - ISSN 0007-1323. - 79:2(1992), pp. 161-164. [10.1002/bjs.1800790222]

Oesophagitis and pH of refluxate: an experimental and clinical study

Zaninotto, G.;di Mario, F.;Baffa, R.;
1992

Abstract

This experimental and clinical study examined the relationship between oesophageal damage and optimal pH of refuxate, and whether 24‐h pH monitoring at optimal pH could discriminate the severity of oesophagitis. The rabbit oesophagus was perfused in vivo with pepsin and hydrochloric acid solutions of difering pH for 60 min. Maximal oesophageal damage coincided with peptic solutions at pH 1.5–2.5. Fifty‐nine patients with proven gastro‐oesophageal reflux disorders were tested for manometric features of the lower oesophageal sphincter (Pressure, overall length and abdominal length) and oesophageal exposure to different pH levels. They were classified into four groups according to the endoscopically demonstrated severity of oesophagitis. Supine exposure at the optimal pH level for pepsin activity (pH 1.5–2.5) and overall sphincter length were found to discriminate the severity of oesophagitis reliably in 75 per cent of cases. Copyright © 1992 British Journal of Surgery Society Ltd.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2844433
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