The theory that Helicobacter pylori infection may be involved in ulcer disease suggests a potential role for antibacterial therapy. To compare three different therapeutic regimens and evaluate their effects on gastric histology and blood parameters, a 4-week study was conducted in which 32 patients with H pylori-related gastroduodenal pathologies (gastritis or gastric or duodenal ulcer) were randomly assigned to one of three treatment groups. Patients in group 1 received amoxicillin for 15 days, then metronidazole for 10 days; those in group 2 received amoxicillin for 15 days, then metronidazole for 10 days, plus colloidal bismuth subcitrate throughout the 25 days of treatment; and those in group 3 received amoxicillin for 15 days, then metronidazole for 10 days, plus omeprazole throughout the 25 days of treatment. To verify whether the pathogen had been eradicated, endoscopy was performed 2 months after treatment was discontinued. No statistically significant differences were seen between the three groups; eradication was achieved in 77% of cases and all therapies were well tolerated. Serum immunoglobulin G levels did not differ before and after treatment. However, serum gastrin and pepsinogen group A levels were found to be significantly lower after eradication, suggesting that these values may provide a noninvasive means of verifying H pylori eradication. Â© 1993 Excerpta Medica, Inc. All rights reserved.
Comparison of three different therapeutic regimens for eradicating Helicobacter pylori / Dotto, P.; Battaglia, G.; Franceschi, M.; Vigneri, S.; Ferrana, M.; Salandin, S.; Dal Bo, N.; Grasso, G. A.; Vianello, F.; Plebani, M.; Guido, M.; Rugge, M.; Di Mario, F.. - In: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL. - ISSN 0011-393X. - 53:5(1993), pp. 557-564. [10.1016/S0011-393X(05)80662-9]
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