Aim of the present study has been to investigate the possible modifications of peptic secretion after a period with H2 blockers and omeprazole, evaluating in the same patient pepsinogen group A levels in gastric mucosa and pepsin in gastric juice. 54 active duodenal ulcer were studied: during an upper gastrointestinal endoscopy a sample of gastric juice and one fundus biopsy were taken before and after four weeks 300 mg/daily ranitidine (23 patients), 40 mg/daily famotidine (7 patients), 300 mg/daily nizatidine (12 patients) therapy and 40 mg/daily omeprazole (12 patients) therapy.
Effects of H2 blockers and omeprazole on peptic secretion: a prospective, randomized study in duodenal ulcer subjects / Di Mario, F; Dotto, P; Vianello, F; Germanà, B; Grassi, S A; Del Favero, G; Faggian, D; Plebani, M; Naccarato, R. - In: ACTA GASTRO-ENTEROLOGICA BELGICA. - ISSN 0001-5644. - 56:2(1993), p. 223-8.
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