Objective: We studied 146 patients with peptic ulcer disease (n = 72), antral gastritis (n = 58), or duodenitis (n = 16) to ascertain whether the cytotoxic genotype of Helicobacter pylori (Hp) is associated with peptic ulcer disease and/or antral gastritis and whether it influences the circulating levels of total anti-Hp antibodies, anti-cagA antibodies, and pepsinogens. Methods: A gastric juice sample was obtained from each patient. After DNA extraction, polymerase chain reaction was used to amplify the genes urease A (ureA), cagA, and vacA of Hp. Results: A significant association was found between peptic ulcer disease and the cytotoxic genotypes, characterized by the presence of s1 and m1 alleles of vacA and by cagA. Patients with a cagA-positive genotype showed a significant increase in anti-cagA antibodies and also had significantly increased circulating levels of pepsinogen C. Conclusions: Cytotoxic Hp strains are mainly involved in determining peptic ulcer disease, but not antral gastritis. The higher levels of circulating pepsinogen C found in patients infected with cytotoxic genotypes may reflect the higher degree of inflammation sustained by these strains.
Helicobacter pylori cytotoxic genotype is associated with peptic ulcer and influences serology / Navaglia, F.; Basso, D.; Piva, M. G.; Brigato, L.; Stefani, A.; Dal Bò, N.; Di Mario, F.; Rugge, M.; Plebani, M.. - In: AMERICAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0002-9270. - 93:2(1998), pp. 227-230. [10.1111/j.1572-0241.1998.00227.x]
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