The thus‐far unknown ureic derivative dimethyl 2,2′‐[carbonylbis(azanediyl)](2S,2′S)‐ bis[3‐(4‐hydroxyphenyl)propanoate] has been efficiently synthesized by enantiospecific oxidative carbonylation of readily available L‐tyrosine methyl ester, using a very simple catalytic system (PdI2 in conjunction with KI) under relatively mild conditions (100 °C for 5 h in DME as the solvent and under 20 atm of a 4:1 mixture CO‐air).

Dimethyl 2,2′‐[carbonylbis(Azanediyl)](2s,2′s)‐bis[3‐(4‐hydroxyphenyl)propanoate] / Mancuso, Raffaella; Gioia, Katia F.; Piccionello, Antonio Palumbo; Della Ca’, Nicola; Carfagna, Carla; Gabriele, Bartolo. - In: MOLBANK. - ISSN 1422-8599. - 2018:1(2018), p. M983. [10.3390/M983]

Dimethyl 2,2′‐[carbonylbis(Azanediyl)](2s,2′s)‐bis[3‐(4‐hydroxyphenyl)propanoate]

Della Ca’, Nicola;
2018

Abstract

The thus‐far unknown ureic derivative dimethyl 2,2′‐[carbonylbis(azanediyl)](2S,2′S)‐ bis[3‐(4‐hydroxyphenyl)propanoate] has been efficiently synthesized by enantiospecific oxidative carbonylation of readily available L‐tyrosine methyl ester, using a very simple catalytic system (PdI2 in conjunction with KI) under relatively mild conditions (100 °C for 5 h in DME as the solvent and under 20 atm of a 4:1 mixture CO‐air).
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2840754
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