Background/Aims: Because the precancerous significance of gastric epithelial dysplasia (GED) is still under debate, this study attempts to ascertain whether a prospective follow-up of GED can contribute to clarifying its clinical and pathological relationships with gastric cancer (GC). Methods: One hundred twelve patients with mild (G1), moderate (G2), and severe (G3) GED or diagnosed as indefinite for dysplasia were prospectively followed up with a standardized endoscopic and bioptic protocol. Results: Evaluation of GED outcome refers only to 93 patients with a follow-up period longer than 12 months. Regression of dysplasia was documented in 36%, 27%, and 0% of G1, G2, and G3 GED cases, respectively. Progression to more severe dysplasia or evolution into GC was detected in 21%, 33%, and 57% of G1, G2, and G3 GED cases, respectively. Evolution into GC was documented for all grades of dysplasia and correlated significantly with high-grade atrophic gastritis. A high prevalence of early GC (86.9%) was also observed. Conclusions: GED is a preinvasive lesion, and carcinomatous evolution increases proportionally with its histological grade. Bioptical follow-up is mandatory for all histological grades of GED and significantly increases the likelihood of GC being detected in its early stages. © 1994.

Gastric epithelial dysplasia in the natural history of gastric cancer: A multicenter prospective follow-up study / Rugge, Massimo; Farinati, Fabio; Baffa, Raffaele; Sonego, Fulvia; Di Mario, Francesco; Leandro, Gioacchino; Valiante, Flavio. - In: GASTROENTEROLOGY. - ISSN 0016-5085. - 107:5(1994), pp. 1288-1296. [10.1016/0016-5085(94)90529-0]

Gastric epithelial dysplasia in the natural history of gastric cancer: A multicenter prospective follow-up study

Rugge, Massimo;BAFFA, RAFFAELE;Di Mario, Francesco;
1994

Abstract

Background/Aims: Because the precancerous significance of gastric epithelial dysplasia (GED) is still under debate, this study attempts to ascertain whether a prospective follow-up of GED can contribute to clarifying its clinical and pathological relationships with gastric cancer (GC). Methods: One hundred twelve patients with mild (G1), moderate (G2), and severe (G3) GED or diagnosed as indefinite for dysplasia were prospectively followed up with a standardized endoscopic and bioptic protocol. Results: Evaluation of GED outcome refers only to 93 patients with a follow-up period longer than 12 months. Regression of dysplasia was documented in 36%, 27%, and 0% of G1, G2, and G3 GED cases, respectively. Progression to more severe dysplasia or evolution into GC was detected in 21%, 33%, and 57% of G1, G2, and G3 GED cases, respectively. Evolution into GC was documented for all grades of dysplasia and correlated significantly with high-grade atrophic gastritis. A high prevalence of early GC (86.9%) was also observed. Conclusions: GED is a preinvasive lesion, and carcinomatous evolution increases proportionally with its histological grade. Bioptical follow-up is mandatory for all histological grades of GED and significantly increases the likelihood of GC being detected in its early stages. © 1994.
Gastric epithelial dysplasia in the natural history of gastric cancer: A multicenter prospective follow-up study / Rugge, Massimo; Farinati, Fabio; Baffa, Raffaele; Sonego, Fulvia; Di Mario, Francesco; Leandro, Gioacchino; Valiante, Flavio. - In: GASTROENTEROLOGY. - ISSN 0016-5085. - 107:5(1994), pp. 1288-1296. [10.1016/0016-5085(94)90529-0]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2840174
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