Background: Bilateral internal mammary artery (BIMA) grafting is increasingly used in the elderly without evidence of its risks or benefits compared to single internal mammary artery (SIMA) grafting. Methods: 2899 patients aged 70 years or older (855 underwent BIMA grafting, 29.5%) operated on from January 2015 to December 2016 and included in the prospective multicenter E-CABG study were considered in this analysis. Results: One-to-one propensity matching resulted in 804 pairs with similar preoperative risk profile. Propensity score matched analysis showed that BIMA grafting was associated with a non-statistically significant increased risk of in-hospital death (2.7% vs 1.6%, p=0.117). BIMA grafting cohort had a significantly increased risk of any sternal wound infection (7.7% vs. 5.1%, p=0.031) as well as higher risk of deep sternal wound infection/mediastinitis (4.0% vs. 2.2%, p=0.048). BIMA grafting cohort required more frequently extracorporeal membrane oxygenation (1.0% vs. 0.1%, p=0.02) and the intensive care unit stay (mean, 3.6 vs. 2.6 days, p<0.001) and in-hospital stay (mean, 11.3 vs. 10.0 days, p<0.001) were significantly longer compared with the SIMA grafting cohort. Test for interaction showed that urgent operation in patients undergoing BIMA grafting was associated with higher risk of in-hospital death (5.6% vs. 1.3%, p=0.009). Conclusions: BIMA grafting in elderly seems to be associated with a worse early outcome compared with SIMA grafting, particularly in patients undergoing urgent operation. Until more conclusive results are gathered, BIMA grafting should be reserved only to elderly patients with stable coronary artery disease, without significant baseline comorbidities and long expectancy of life.

Early Outcome of Bilateral versus Single Internal Mammary Artery Grafting in the Elderly / Rubino, As; Gatti, G; Reichart, D; Tauriainen, T; De Feo, M; Onorati, F; Pappalardo, A; Chocron, S; Gulbins, H; Dalén, M; Svenarud, P; Faggian, G; Franzese, I; Santarpino, G; Fischlein, T; Maselli, D; Nardella, S; Gherli, R; Ahmed, A; Santini, F; Salsano, A; Nicolini, F; Zanobini, M; Saccocci, M; Ruggieri, Vg; Bounader, K; Mignosa, C; D'Errigo, P; Rosato, S; Airaksinen, J; Perrotti, A; Biancari, F. - In: ANNALS OF THORACIC SURGERY. - ISSN 0003-4975. - 105:6(2018), pp. 1717-1723. [10.1016/j.athoracsur.2017.11.079]

Early Outcome of Bilateral versus Single Internal Mammary Artery Grafting in the Elderly.

Nicolini F;
2018

Abstract

Background: Bilateral internal mammary artery (BIMA) grafting is increasingly used in the elderly without evidence of its risks or benefits compared to single internal mammary artery (SIMA) grafting. Methods: 2899 patients aged 70 years or older (855 underwent BIMA grafting, 29.5%) operated on from January 2015 to December 2016 and included in the prospective multicenter E-CABG study were considered in this analysis. Results: One-to-one propensity matching resulted in 804 pairs with similar preoperative risk profile. Propensity score matched analysis showed that BIMA grafting was associated with a non-statistically significant increased risk of in-hospital death (2.7% vs 1.6%, p=0.117). BIMA grafting cohort had a significantly increased risk of any sternal wound infection (7.7% vs. 5.1%, p=0.031) as well as higher risk of deep sternal wound infection/mediastinitis (4.0% vs. 2.2%, p=0.048). BIMA grafting cohort required more frequently extracorporeal membrane oxygenation (1.0% vs. 0.1%, p=0.02) and the intensive care unit stay (mean, 3.6 vs. 2.6 days, p<0.001) and in-hospital stay (mean, 11.3 vs. 10.0 days, p<0.001) were significantly longer compared with the SIMA grafting cohort. Test for interaction showed that urgent operation in patients undergoing BIMA grafting was associated with higher risk of in-hospital death (5.6% vs. 1.3%, p=0.009). Conclusions: BIMA grafting in elderly seems to be associated with a worse early outcome compared with SIMA grafting, particularly in patients undergoing urgent operation. Until more conclusive results are gathered, BIMA grafting should be reserved only to elderly patients with stable coronary artery disease, without significant baseline comorbidities and long expectancy of life.
Early Outcome of Bilateral versus Single Internal Mammary Artery Grafting in the Elderly / Rubino, As; Gatti, G; Reichart, D; Tauriainen, T; De Feo, M; Onorati, F; Pappalardo, A; Chocron, S; Gulbins, H; Dalén, M; Svenarud, P; Faggian, G; Franzese, I; Santarpino, G; Fischlein, T; Maselli, D; Nardella, S; Gherli, R; Ahmed, A; Santini, F; Salsano, A; Nicolini, F; Zanobini, M; Saccocci, M; Ruggieri, Vg; Bounader, K; Mignosa, C; D'Errigo, P; Rosato, S; Airaksinen, J; Perrotti, A; Biancari, F. - In: ANNALS OF THORACIC SURGERY. - ISSN 0003-4975. - 105:6(2018), pp. 1717-1723. [10.1016/j.athoracsur.2017.11.079]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2839825
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