Background The prognosticimpactofcross-clamptime(XCT)inpatientsundergoingisolatedcoronaryarterybypass grafting (CABG)hasnotbeenthoroughlyinvestigated. Material and Methods 2957 patientswhounderwenton-pumpisolatedCABGfromtheprospectivemulticentreE-CABGstudy were thesubjectsofthisanalysis. The meanXCTinthisserieswas58 25 [21TD$DIF]minutes Cross-clamptimewas >60 [2TD$DIF]minutes in1134patients (38.3%), >75 [2TD$DIF]minutes in619patients(20.9%)and >90 [2TD$DIF]minutes in296patients(10.0%).Multivariateanalysis showed thatXCTwasanindependentpredictorof30-daymortality(p < 0.0001, OR1.027,95%CI1.015– 1.039) alongwithage(p < 0.0001), femalegender(p=0.001),pulmonarydisease(p=0.001),poormobility (p =0.002),urgencystatus(p=0.007),criticalpreoperativestatus(p=0.002)andparticipatingcentres (p =0.015).Adjustedriskof30-daymortalitywashighestforXCT >75 [2TD$DIF]minutes (2.9%vs.1.7%,p=0.002, OR 3.479,95%CI1.609–7.520).Analysisof428propensityscorematchedpairsshowedthatXCT >75 [2TD$DIF] minutes wasassociatedwithsignificantlyincreasedriskofearlymortality,prolongeduseofinotropes, postoperative useofintra-aorticballoonpump,useofextracorporealmembraneoxygenation,atrialfibrilla- tion, prolongedstayintheintensivecareunitandofcompositemajoradverseevents. Conclusions Isolated CABGiscurrentlyperformedwithprolongedXCTinasignificantnumberofpatientsandthis seems tobeadeterminantofpoorearlyoutcome.

Prognostic Impact of Prolonged Cross-Clamp Time in Coronary Artery Bypass Grafting / Ruggieri, Vg; Bounader, K; Verhoye, Jp; Onorati, F; Rubino, As; Gatti, G; Tauriainen, T; De Feo, M; Reichart, D; Dalén, M; Svenarud, P; Faggian, G; Santarpino, G; Maselli, D; Gherli, R; Mariscalco, G; Salsano, A; Nicolini, F; Gherli, T; Saccocci, M; Airaksinen, Jke; Chocron, S; Perrotti, A; Biancari, F.. - In: HEART LUNG & CIRCULATION. - ISSN 1443-9506. - 27:12(2018), pp. 1476-1482. [10.1016/j.hlc.2017.09.006]

Prognostic Impact of Prolonged Cross-Clamp Time in Coronary Artery Bypass Grafting.

Nicolini F;Gherli T;
2018

Abstract

Background The prognosticimpactofcross-clamptime(XCT)inpatientsundergoingisolatedcoronaryarterybypass grafting (CABG)hasnotbeenthoroughlyinvestigated. Material and Methods 2957 patientswhounderwenton-pumpisolatedCABGfromtheprospectivemulticentreE-CABGstudy were thesubjectsofthisanalysis. The meanXCTinthisserieswas58 25 [21TD$DIF]minutes Cross-clamptimewas >60 [2TD$DIF]minutes in1134patients (38.3%), >75 [2TD$DIF]minutes in619patients(20.9%)and >90 [2TD$DIF]minutes in296patients(10.0%).Multivariateanalysis showed thatXCTwasanindependentpredictorof30-daymortality(p < 0.0001, OR1.027,95%CI1.015– 1.039) alongwithage(p < 0.0001), femalegender(p=0.001),pulmonarydisease(p=0.001),poormobility (p =0.002),urgencystatus(p=0.007),criticalpreoperativestatus(p=0.002)andparticipatingcentres (p =0.015).Adjustedriskof30-daymortalitywashighestforXCT >75 [2TD$DIF]minutes (2.9%vs.1.7%,p=0.002, OR 3.479,95%CI1.609–7.520).Analysisof428propensityscorematchedpairsshowedthatXCT >75 [2TD$DIF] minutes wasassociatedwithsignificantlyincreasedriskofearlymortality,prolongeduseofinotropes, postoperative useofintra-aorticballoonpump,useofextracorporealmembraneoxygenation,atrialfibrilla- tion, prolongedstayintheintensivecareunitandofcompositemajoradverseevents. Conclusions Isolated CABGiscurrentlyperformedwithprolongedXCTinasignificantnumberofpatientsandthis seems tobeadeterminantofpoorearlyoutcome.
Prognostic Impact of Prolonged Cross-Clamp Time in Coronary Artery Bypass Grafting / Ruggieri, Vg; Bounader, K; Verhoye, Jp; Onorati, F; Rubino, As; Gatti, G; Tauriainen, T; De Feo, M; Reichart, D; Dalén, M; Svenarud, P; Faggian, G; Santarpino, G; Maselli, D; Gherli, R; Mariscalco, G; Salsano, A; Nicolini, F; Gherli, T; Saccocci, M; Airaksinen, Jke; Chocron, S; Perrotti, A; Biancari, F.. - In: HEART LUNG & CIRCULATION. - ISSN 1443-9506. - 27:12(2018), pp. 1476-1482. [10.1016/j.hlc.2017.09.006]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2839737
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