The effects of atherogenic lipoproteins on the release of tissue plasminogen activator inhibitor (PAI-1) by endothelial cells were evaluated. Incubation of cultured human umbilical vein endothelial cells (EC) with very low density (VLDL) and low density (LDL) lipoproteins induced a two fold increase of PAI-1 release by EC. Similarly acetylated LDL (acetyl-LDL) stimulated PAI-1 release by EC, whereas oxidized LDL (ox-LDL) reduced it. It is concluded that atherogenic lipoproteins profoundly influence the capacity of EC to release proteins with thrombogenic properties.
Atherogenic lipoproteins and release of plasminogen activator inhibitor-1 (PAI-1) by endothelial cells / Mussoni, L.; Madema, P.; Camera, M.; Bernini, F.; Sironi, L.; Sirtori, M.; Tremoli, E.. - In: FIBRINOLYSIS. - ISSN 0268-9499. - 4:2(1990), pp. 79-81. [10.1016/0268-9499(90)90367-S]
Atherogenic lipoproteins and release of plasminogen activator inhibitor-1 (PAI-1) by endothelial cells
Bernini F.;
1990-01-01
Abstract
The effects of atherogenic lipoproteins on the release of tissue plasminogen activator inhibitor (PAI-1) by endothelial cells were evaluated. Incubation of cultured human umbilical vein endothelial cells (EC) with very low density (VLDL) and low density (LDL) lipoproteins induced a two fold increase of PAI-1 release by EC. Similarly acetylated LDL (acetyl-LDL) stimulated PAI-1 release by EC, whereas oxidized LDL (ox-LDL) reduced it. It is concluded that atherogenic lipoproteins profoundly influence the capacity of EC to release proteins with thrombogenic properties.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
