Oxygenated derivatives of cholesterol are believed to play a role in cellular cholesterol homeostasis through the feed-back control of its biosynthesis. We report that 26-hydroxycholesterol inhibits the specific binding, uptake and degradation of 125I-LDL in human fibroblasts. The effect is dose-dependent, and saturation kinetics indicates a reduction of LDL-binding sites with no effect on ligand affinity. The results support a possible role of 26-hydroxycholesterol, a physiological oxysterol, in the regulation of cellular cholesterol homeostasis.
Regulation of low density lipoprotein metabolism by 26-hydroxycholesterol in human fibroblasts / Lorenzo, J. L.; Allorio, M.; Bernini, F.; Corsini, A.; Fumagalli, R. - In: FEBS LETTERS. - ISSN 0014-5793. - 218:1(1987), pp. 77-80. [10.1016/0014-5793(87)81022-0]
Regulation of low density lipoprotein metabolism by 26-hydroxycholesterol in human fibroblasts
Bernini F.;
1987-01-01
Abstract
Oxygenated derivatives of cholesterol are believed to play a role in cellular cholesterol homeostasis through the feed-back control of its biosynthesis. We report that 26-hydroxycholesterol inhibits the specific binding, uptake and degradation of 125I-LDL in human fibroblasts. The effect is dose-dependent, and saturation kinetics indicates a reduction of LDL-binding sites with no effect on ligand affinity. The results support a possible role of 26-hydroxycholesterol, a physiological oxysterol, in the regulation of cellular cholesterol homeostasis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.