Previously, we observed that a single low-intensity premature ventricular stimulation could occasionally induce spontaneous ectopic beats in normal rat hearts. Possible hypothesis for the arrhythmia is that a premature beat can encounter a zone of conduction block to initiate reentry. However, enhanced dispersion of repolarization, a necessary condition for initiation of reentry, is unlikely to be present in normal myocardium. Thus, the main objective of the present study was to perform detailed pace mapping measurements in normal ventricular myocardium with a view to identify pacing sites and critical coupling intervals which could induce spontaneous ectopic beats and to characterize the reentrant circuits.

Can a single low-intensity premature stimulus induce ventricular arrhythmias in the normal heart? / Rossi, Stefano; Baruffi, Silvana; Callegari, Sergio; Carnevali, Luca; Corradi, Domenico; Miragoli, Michele; Musso, Ezio; Sgoifo, Andrea; Trombini, Mimosa; Macchi, Emilio. - In: JOURNAL OF BIOLOGICAL RESEARCH. - ISSN 1826-8838. - 87:1(2014). [10.4081/jbr.2014.2128]

Can a single low-intensity premature stimulus induce ventricular arrhythmias in the normal heart?

Rossi, Stefano;Baruffi, Silvana;Callegari, Sergio;Carnevali, Luca;Corradi, Domenico;Miragoli, Michele;Musso, Ezio;Sgoifo, Andrea;Trombini, Mimosa;Macchi, Emilio
2014

Abstract

Previously, we observed that a single low-intensity premature ventricular stimulation could occasionally induce spontaneous ectopic beats in normal rat hearts. Possible hypothesis for the arrhythmia is that a premature beat can encounter a zone of conduction block to initiate reentry. However, enhanced dispersion of repolarization, a necessary condition for initiation of reentry, is unlikely to be present in normal myocardium. Thus, the main objective of the present study was to perform detailed pace mapping measurements in normal ventricular myocardium with a view to identify pacing sites and critical coupling intervals which could induce spontaneous ectopic beats and to characterize the reentrant circuits.
Can a single low-intensity premature stimulus induce ventricular arrhythmias in the normal heart? / Rossi, Stefano; Baruffi, Silvana; Callegari, Sergio; Carnevali, Luca; Corradi, Domenico; Miragoli, Michele; Musso, Ezio; Sgoifo, Andrea; Trombini, Mimosa; Macchi, Emilio. - In: JOURNAL OF BIOLOGICAL RESEARCH. - ISSN 1826-8838. - 87:1(2014). [10.4081/jbr.2014.2128]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2838977
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? ND
social impact