Purpose: To describe outcome and changes in clotting and inflammatory parameters in an uncontrolled case series of consecutive patients with severe sepsis who received protein C concentrate soon after cardiac surgery. Methods: From January 2007 to January 2008 nine consecutive adult patients with severe sepsis or septic shock and two or more organ failure after cardiac surgery received protein C concentrate, 50 IU/kg as a bolus followed by continuous infusion of 3 IU/kg per hour for 72 h. Results: The increase in protein C levels was accompanied by an early drop in interleukins and near-normalization of prothrombin time, activated partial thromboplastin time, antithrombin and thrombin-antithrombin complex levels (p ≤ 0.03). No patient experienced drug-related side effects. Thirty-day mortality was 11% (1 patient) compared to the expected mortality of 68%. Conclusions: In this pilot, uncontrolled study of nine patients with sepsis-induced double organ failure following cardiac surgery, treatment with protein C concentrate was associated with significant improvement in clinical, inflammatory and clotting parameters, no bleeding and low 30-day mortality. © Springer-Verlag 2009.

Human protein C zymogen concentrate in patients with severe sepsis and multiple organ failure after adult cardiac surgery / Crivellari, Martina; Valle, Patrizia Della; Landoni, Giovanni; Pappalardo, Federico; Gerli, Chiara; Bignami, Elena; Marino, Giovanni; Zangrillo, Alberto; D'Angelo, Armando. - In: INTENSIVE CARE MEDICINE. - ISSN 0342-4642. - 35:11(2009), pp. 1959-1963. [10.1007/s00134-009-1584-3]

Human protein C zymogen concentrate in patients with severe sepsis and multiple organ failure after adult cardiac surgery

Bignami, Elena;MARINO, GIOVANNI;
2009

Abstract

Purpose: To describe outcome and changes in clotting and inflammatory parameters in an uncontrolled case series of consecutive patients with severe sepsis who received protein C concentrate soon after cardiac surgery. Methods: From January 2007 to January 2008 nine consecutive adult patients with severe sepsis or septic shock and two or more organ failure after cardiac surgery received protein C concentrate, 50 IU/kg as a bolus followed by continuous infusion of 3 IU/kg per hour for 72 h. Results: The increase in protein C levels was accompanied by an early drop in interleukins and near-normalization of prothrombin time, activated partial thromboplastin time, antithrombin and thrombin-antithrombin complex levels (p ≤ 0.03). No patient experienced drug-related side effects. Thirty-day mortality was 11% (1 patient) compared to the expected mortality of 68%. Conclusions: In this pilot, uncontrolled study of nine patients with sepsis-induced double organ failure following cardiac surgery, treatment with protein C concentrate was associated with significant improvement in clinical, inflammatory and clotting parameters, no bleeding and low 30-day mortality. © Springer-Verlag 2009.
Human protein C zymogen concentrate in patients with severe sepsis and multiple organ failure after adult cardiac surgery / Crivellari, Martina; Valle, Patrizia Della; Landoni, Giovanni; Pappalardo, Federico; Gerli, Chiara; Bignami, Elena; Marino, Giovanni; Zangrillo, Alberto; D'Angelo, Armando. - In: INTENSIVE CARE MEDICINE. - ISSN 0342-4642. - 35:11(2009), pp. 1959-1963. [10.1007/s00134-009-1584-3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2838927
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