Severe sepsis and septic shock are leading causes of morbidity and mortality in the pediatric population. Unlike what is suggested for the adult population, recombinant human activated protein C (rhAPC) is contraindicated in children. Long before rhAPC was considered for use in pediatric patients, case reports appeared on the safe administration of protein C zymogen. Therefore, we conducted a systemic review of currently available data on protein C zymogen (PC) use among children affected by severe sepsis or septic shock. A total number of 13 case series or case reports and a dose-finding study were found on the use of PC in the pediatric intensive care unit, reporting on 118 treated children, with an overall survival of 84%. There was no bleeding complication, the only reported complication being a single mild allergic reaction These studies show that PC is safe, not associated with bleeding and possibly useful for improving coagulation abnormalities of sepsis.

Human protein C concentrate in pediatric septic patients / Landoni, Giovanni; Monti, Giacomo; Facchini, Alberto; Cama, Francesco; Bignami, Elena; Cabrini, Luca; Pappalardo, Federico; Zangrillo, Alberto. - In: SIGNA VITAE. - ISSN 1334-5605. - 5:1(2010), pp. 13-19. [10.22514/SV51.042010.2]

Human protein C concentrate in pediatric septic patients

Bignami, Elena;
2010

Abstract

Severe sepsis and septic shock are leading causes of morbidity and mortality in the pediatric population. Unlike what is suggested for the adult population, recombinant human activated protein C (rhAPC) is contraindicated in children. Long before rhAPC was considered for use in pediatric patients, case reports appeared on the safe administration of protein C zymogen. Therefore, we conducted a systemic review of currently available data on protein C zymogen (PC) use among children affected by severe sepsis or septic shock. A total number of 13 case series or case reports and a dose-finding study were found on the use of PC in the pediatric intensive care unit, reporting on 118 treated children, with an overall survival of 84%. There was no bleeding complication, the only reported complication being a single mild allergic reaction These studies show that PC is safe, not associated with bleeding and possibly useful for improving coagulation abnormalities of sepsis.
Human protein C concentrate in pediatric septic patients / Landoni, Giovanni; Monti, Giacomo; Facchini, Alberto; Cama, Francesco; Bignami, Elena; Cabrini, Luca; Pappalardo, Federico; Zangrillo, Alberto. - In: SIGNA VITAE. - ISSN 1334-5605. - 5:1(2010), pp. 13-19. [10.22514/SV51.042010.2]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2838918
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