Atrial fibrillation (AF) is the most common cause of thromboembolic complications. The risk of suffering a thromboembolic complication depends on the accompanying cardiac risk factors and the patient’s age. For patients who have an increased risk, which is now classified using the CHA2DS2-VASc score, initiation of long-term oral anticoagulation is the first-line treatment. In AF, thrombi arise in the left atrial appendage. The present review will summarize the basic pathophysiology of thrombogenesis in AF and will provide the molecular basis of a process called prothrombotic endocardial remodeling. Despite oral anticoagulation being a central component of therapy, the present results can be used to support concomitant therapy with statins, angiotensin II blockers, etc. to inhibit atrial thromogenesis.

Atrial thrombogenesis in atrial fibrillation: results from atrial fibrillation models and AF-patients / Bukowska, Alicja; Hammwöhner, Matthias; Corradi, Domenico; Mahardhika, Wisno; Goette, Andreas. - In: HERZSCHRITTMACHERTHERAPIE & ELEKTROPHYSIOLOGIE. - ISSN 0938-7412. - (2017). [10.1007/s00399-017-0543-x]

Atrial thrombogenesis in atrial fibrillation: results from atrial fibrillation models and AF-patients.

Corradi, Domenico;
2017

Abstract

Atrial fibrillation (AF) is the most common cause of thromboembolic complications. The risk of suffering a thromboembolic complication depends on the accompanying cardiac risk factors and the patient’s age. For patients who have an increased risk, which is now classified using the CHA2DS2-VASc score, initiation of long-term oral anticoagulation is the first-line treatment. In AF, thrombi arise in the left atrial appendage. The present review will summarize the basic pathophysiology of thrombogenesis in AF and will provide the molecular basis of a process called prothrombotic endocardial remodeling. Despite oral anticoagulation being a central component of therapy, the present results can be used to support concomitant therapy with statins, angiotensin II blockers, etc. to inhibit atrial thromogenesis.
Atrial thrombogenesis in atrial fibrillation: results from atrial fibrillation models and AF-patients / Bukowska, Alicja; Hammwöhner, Matthias; Corradi, Domenico; Mahardhika, Wisno; Goette, Andreas. - In: HERZSCHRITTMACHERTHERAPIE & ELEKTROPHYSIOLOGIE. - ISSN 0938-7412. - (2017). [10.1007/s00399-017-0543-x]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2838394
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