Bifidobacteria are among the first microbial colonisers of the human infant gut post-partum. Their early appearance and dominance in the human infant gut and the reported health-promoting or probiotic status of several bifidobacterial strains has culminated in intensive research efforts that focus on their activities as part of the gut microbiota and the concomitant implications for human health. In this mini-review, we evaluate current knowledge on the genomics of this diverse bacterial genus, and on the genetic and functional adaptations that have underpinned the success of bifidobacteria in colonising the infant gut. The growing interest in functional genomics of bifidobacteria has also created interest in the interactions of bifidobacteria and their (bacterio)phages. While virulent phages of bifidobacteria have yet to be isolated, the incidence of integrated (pro)phages in bifidobacterial genomes are widely reported and this mini-review considers the role of these so-called bifidoprophages in modulating bifidobacterial populations in the human gastrointestinal tract and the implications for existing and future development of probiotic therapies.

Impact of gut-associated bifidobacteria and their phages on health: two sides of the same coin? / Mahony, Jennifer; Lugli, Gabriele Andrea; VAN SINDEREN, Douwe; Ventura, Marco. - In: APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. - ISSN 0175-7598. - 102:5(2018), pp. 2091-2099. [10.1007/s00253-018-8795-x]

Impact of gut-associated bifidobacteria and their phages on health: two sides of the same coin?

LUGLI, Gabriele Andrea;VAN SINDEREN, DOUWE;Ventura, Marco
2018

Abstract

Bifidobacteria are among the first microbial colonisers of the human infant gut post-partum. Their early appearance and dominance in the human infant gut and the reported health-promoting or probiotic status of several bifidobacterial strains has culminated in intensive research efforts that focus on their activities as part of the gut microbiota and the concomitant implications for human health. In this mini-review, we evaluate current knowledge on the genomics of this diverse bacterial genus, and on the genetic and functional adaptations that have underpinned the success of bifidobacteria in colonising the infant gut. The growing interest in functional genomics of bifidobacteria has also created interest in the interactions of bifidobacteria and their (bacterio)phages. While virulent phages of bifidobacteria have yet to be isolated, the incidence of integrated (pro)phages in bifidobacterial genomes are widely reported and this mini-review considers the role of these so-called bifidoprophages in modulating bifidobacterial populations in the human gastrointestinal tract and the implications for existing and future development of probiotic therapies.
Impact of gut-associated bifidobacteria and their phages on health: two sides of the same coin? / Mahony, Jennifer; Lugli, Gabriele Andrea; VAN SINDEREN, Douwe; Ventura, Marco. - In: APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. - ISSN 0175-7598. - 102:5(2018), pp. 2091-2099. [10.1007/s00253-018-8795-x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2838344
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