The objective of the present study was to investigate the ability of n-butanol extract obtained from Rhantherium suaveolens aerial parts and vitamin E to modulate valproic acid-induced hepatotoxicity and oxidative damage in pregnant mice. Valproic acid (VPA) injection in mice at a dose of 300 mg/kg induced hepatic dysfunction revealed by a significant increase in the serum of AST and ALT. The pretreatment of mice with vitamin E (100 mg/kg) and butanol extract (100 mg/kg) protected liver cells from oxidative stress permitting the prevention of liver injury. Histopathological observations also correlated with the biochemical parameters. The polyphenolic compounds of this extract probably confer protection against oxidative stress generated in liver by VPA.
Effet hépatoprotecteur et antiradicalaire dâun extrait butanolique de Rhantherium suaveolens / Amrani, A.; Benaissa, O.; Boubekri, N.; Zama, D.; Biod, K.; Beroal, N.; Benayache, F.; Benayache, S.; Bettuzzi, S.. - In: PHYTOTHÉRAPIE. - ISSN 1624-8597. - 12:6(2014), pp. 386-392. [10.1007/s10298-014-0871-5]
Effet hépatoprotecteur et antiradicalaire dâun extrait butanolique de Rhantherium suaveolens
Bettuzzi, S.
2014-01-01
Abstract
The objective of the present study was to investigate the ability of n-butanol extract obtained from Rhantherium suaveolens aerial parts and vitamin E to modulate valproic acid-induced hepatotoxicity and oxidative damage in pregnant mice. Valproic acid (VPA) injection in mice at a dose of 300 mg/kg induced hepatic dysfunction revealed by a significant increase in the serum of AST and ALT. The pretreatment of mice with vitamin E (100 mg/kg) and butanol extract (100 mg/kg) protected liver cells from oxidative stress permitting the prevention of liver injury. Histopathological observations also correlated with the biochemical parameters. The polyphenolic compounds of this extract probably confer protection against oxidative stress generated in liver by VPA.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
