Context: Urinary S-phenylmercapturic acid (SPMA) and benzene (U-Ben) are usually measured at the end of the work shift (ES), although their kinetic of elimination is not clearly known. Objective: To investigate SPMA and U-Ben elimination 16 h after the ES, in 93 coke production workers exposed to low benzene concentrations. Materials and methods: Airborne benzene (A-Ben) was measured by passive samplings, while SPMA, U-Ben, methyl-tert-butyl ether (U-MTBE), cotinine (U-Cot) and creatinine were determined on urine samples collected at ES and before the beginning of the next work shift (next BS). Results: Median A-Ben concentrations were 17.2 µg/m3in the personal and 34.7 µg/m3in the stationary samplings. SPMA was always detectable, whereas U-Ben was below the limit of quantification in 26.7% of the ES and 35.6% of the next BS samples, and U-MTBE in more than the 80.0% of the samples. At both the sampling times, SPMA and U-Ben showed a positive dependence on personal A-Ben, as well as on creatinine and U-Cot values. Discussion and conclusion: SPMA and U-Ben at the next BS were dependent on the exposure to low benzene concentrations suffered in the previous work shift, prompting a reconsideration of the urine sampling time recommended by the American Conference Governmental Industrial Hygienists (ACGIH).

Biological monitoring of exposure to low concentrations of benzene in workers at a metallurgical coke production plant: new insights into S-phenylmercapturic acid and urinary benzene / Lovreglio, Piero; De Palma, Giuseppe; Barbieri, Anna; Andreoli, Roberta; Drago, Ignazio; Greco, Luciano; Gallo, Elisabetta; Diomede, Laura; Scaramuzzo, Pietro; Ricossa, Maria Cristina; Fostinelli, Jacopo; Apostoli, Pietro; Soleo, Leonardo. - In: BIOMARKERS. - ISSN 1354-750X. - (2017), pp. 1-8. [10.1080/1354750X.2017.1387935]

Biological monitoring of exposure to low concentrations of benzene in workers at a metallurgical coke production plant: new insights into S-phenylmercapturic acid and urinary benzene

De Palma, Giuseppe;Andreoli, Roberta;Apostoli, Pietro;
2017

Abstract

Context: Urinary S-phenylmercapturic acid (SPMA) and benzene (U-Ben) are usually measured at the end of the work shift (ES), although their kinetic of elimination is not clearly known. Objective: To investigate SPMA and U-Ben elimination 16 h after the ES, in 93 coke production workers exposed to low benzene concentrations. Materials and methods: Airborne benzene (A-Ben) was measured by passive samplings, while SPMA, U-Ben, methyl-tert-butyl ether (U-MTBE), cotinine (U-Cot) and creatinine were determined on urine samples collected at ES and before the beginning of the next work shift (next BS). Results: Median A-Ben concentrations were 17.2 µg/m3in the personal and 34.7 µg/m3in the stationary samplings. SPMA was always detectable, whereas U-Ben was below the limit of quantification in 26.7% of the ES and 35.6% of the next BS samples, and U-MTBE in more than the 80.0% of the samples. At both the sampling times, SPMA and U-Ben showed a positive dependence on personal A-Ben, as well as on creatinine and U-Cot values. Discussion and conclusion: SPMA and U-Ben at the next BS were dependent on the exposure to low benzene concentrations suffered in the previous work shift, prompting a reconsideration of the urine sampling time recommended by the American Conference Governmental Industrial Hygienists (ACGIH).
Biological monitoring of exposure to low concentrations of benzene in workers at a metallurgical coke production plant: new insights into S-phenylmercapturic acid and urinary benzene / Lovreglio, Piero; De Palma, Giuseppe; Barbieri, Anna; Andreoli, Roberta; Drago, Ignazio; Greco, Luciano; Gallo, Elisabetta; Diomede, Laura; Scaramuzzo, Pietro; Ricossa, Maria Cristina; Fostinelli, Jacopo; Apostoli, Pietro; Soleo, Leonardo. - In: BIOMARKERS. - ISSN 1354-750X. - (2017), pp. 1-8. [10.1080/1354750X.2017.1387935]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2837313
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