Previous studies have indicated that workers exposed to styrene present a decreased activity of platelet monoamine oxidase B (MAO B), suggesting that this biochemical assay may represent a biomarker for styrene-induced neurotoxicity. This study was undertaken to determine whether exposure to styrene would cause changes in MAO B activity in the target organ-the brain. Groups of rats were exposed to styrene by inhalation at concentrations of 300 ppm for 4 wk or 50 ppm for 13 wk. Both treatments caused significant decreases of MAO B activity in several brain areas, while MAO A activity was not affected. Decreases in MAO B activity were also found in brainstem of rats given styrene (400 mg/ kg) or styrene oxide (100 mg/ kg) by ip injection for 2 wk. Styrene, styrene oxide, and other styrene metabolites (mandelic acid, phenylglyoxylic acid, and styrene glycol) had no direct inhibitory effect on brain MAO B activity when tested in vitro. These results indicate that exposure to low concentrations of styrene alters MAO B activity in rat brain, suggesting that the observed changes in human platelets may reflect alterations in the nervous system. © 1999 Taylor & Francis Group, LLC.

Effect of styrene on monoamine oxidase b activity in rat brain / Coccini, Teresa; Randine, Giovanna; Li, Bin; Manzo, Luigi; Costa, Lucio G.. - In: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH. PART A. - ISSN 1528-7394. - 56:1(1999), pp. 59-68. [10.1080/009841099158231]

Effect of styrene on monoamine oxidase b activity in rat brain

Costa, Lucio G.
1999-01-01

Abstract

Previous studies have indicated that workers exposed to styrene present a decreased activity of platelet monoamine oxidase B (MAO B), suggesting that this biochemical assay may represent a biomarker for styrene-induced neurotoxicity. This study was undertaken to determine whether exposure to styrene would cause changes in MAO B activity in the target organ-the brain. Groups of rats were exposed to styrene by inhalation at concentrations of 300 ppm for 4 wk or 50 ppm for 13 wk. Both treatments caused significant decreases of MAO B activity in several brain areas, while MAO A activity was not affected. Decreases in MAO B activity were also found in brainstem of rats given styrene (400 mg/ kg) or styrene oxide (100 mg/ kg) by ip injection for 2 wk. Styrene, styrene oxide, and other styrene metabolites (mandelic acid, phenylglyoxylic acid, and styrene glycol) had no direct inhibitory effect on brain MAO B activity when tested in vitro. These results indicate that exposure to low concentrations of styrene alters MAO B activity in rat brain, suggesting that the observed changes in human platelets may reflect alterations in the nervous system. © 1999 Taylor & Francis Group, LLC.
Effect of styrene on monoamine oxidase b activity in rat brain / Coccini, Teresa; Randine, Giovanna; Li, Bin; Manzo, Luigi; Costa, Lucio G.. - In: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH. PART A. - ISSN 1528-7394. - 56:1(1999), pp. 59-68. [10.1080/009841099158231]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2837197
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 9
  • ???jsp.display-item.citation.isi??? ND
social impact