In a population-based case-control study, we found a reversal of the association of cigarette smoking with Parkinson's disease (PD) in relation to the monoamine oxidase B intron 13 genetic polymorphism. A reduced PD risk related to pack-years of smoking was detected for persons with the G allele, whereas an opposite effect was found among persons with the A allele. These results indicate an unexplained interaction between cigarette smoking and this genetic polymorphism.

A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease / Checkoway, H; Franklin, G. M; Costa-Mallen, P; Smith-Weller, T; Dilley, J; Swanson, P. D; Costa, L. G.. - In: NEUROLOGY. - ISSN 0028-3878. - 50:5(1998), p. 1458-61.

A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease

Costa, L. G.
1998-01-01

Abstract

In a population-based case-control study, we found a reversal of the association of cigarette smoking with Parkinson's disease (PD) in relation to the monoamine oxidase B intron 13 genetic polymorphism. A reduced PD risk related to pack-years of smoking was detected for persons with the G allele, whereas an opposite effect was found among persons with the A allele. These results indicate an unexplained interaction between cigarette smoking and this genetic polymorphism.
A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease / Checkoway, H; Franklin, G. M; Costa-Mallen, P; Smith-Weller, T; Dilley, J; Swanson, P. D; Costa, L. G.. - In: NEUROLOGY. - ISSN 0028-3878. - 50:5(1998), p. 1458-61.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2837184
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