Male Swiss albino mice (CD-1) were given single doses of [14C]carmoisine by stomach tube (200 mg/kg, 6 μCi) or iv injection (200 mg/kg; 0·7 μCi). The plasma and tissue kinetics of the compound were studied by monitoring the decay of radioactivity in the plasma, gastro-intestinal tract, liver, kidney, lung, testes, spleen and gall bladder. The faeces and urine of mice placed in individual metabolism cages were collected between 4 and 96 hr after dosing. After oral administration peak levels of radioactivity occurred in the plasma and the liver, lungs, testes and spleen 8 hr after dosing. Radioactivity was almost completely (98%) excreted in the faeces and urine within 16-32 hr after oral dosing. The plasma [14C]radioactivity decay curve after iv administration indicated a very rapid distribution of the compound into the tissues (t1 2= 10 min) and an efficient excretion, mostly through the gastro-intestinal tract (92%), which was complete 48 hr after dosing. © 1981.

Absorption, distribution and excretion of [14C]carmoisine in mice after oral and intravenous administration / Galli, C. L.; Marinovich, M.; Costa, L. G.. - In: FOOD AND COSMETICS TOXICOLOGY. - ISSN 0015-6264. - 19:C(1981), pp. 413-418. [10.1016/0015-6264(81)90443-0]

Absorption, distribution and excretion of [14C]carmoisine in mice after oral and intravenous administration

Costa, L. G.
1981

Abstract

Male Swiss albino mice (CD-1) were given single doses of [14C]carmoisine by stomach tube (200 mg/kg, 6 μCi) or iv injection (200 mg/kg; 0·7 μCi). The plasma and tissue kinetics of the compound were studied by monitoring the decay of radioactivity in the plasma, gastro-intestinal tract, liver, kidney, lung, testes, spleen and gall bladder. The faeces and urine of mice placed in individual metabolism cages were collected between 4 and 96 hr after dosing. After oral administration peak levels of radioactivity occurred in the plasma and the liver, lungs, testes and spleen 8 hr after dosing. Radioactivity was almost completely (98%) excreted in the faeces and urine within 16-32 hr after oral dosing. The plasma [14C]radioactivity decay curve after iv administration indicated a very rapid distribution of the compound into the tissues (t1 2= 10 min) and an efficient excretion, mostly through the gastro-intestinal tract (92%), which was complete 48 hr after dosing. © 1981.
Absorption, distribution and excretion of [14C]carmoisine in mice after oral and intravenous administration / Galli, C. L.; Marinovich, M.; Costa, L. G.. - In: FOOD AND COSMETICS TOXICOLOGY. - ISSN 0015-6264. - 19:C(1981), pp. 413-418. [10.1016/0015-6264(81)90443-0]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2837046
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