Pregnant Sprague-Dawley rats received [14C]Carmoisine (200 mg/kg; 25 Î¼Ci) by gavage, on days 16-19 of gestation. Animals were killed on day 19 of gestation, 2, 16, 64 h after dosing and blood, maternal tissues, amniotic fluids, placentae, fetal membranes and fetuses were analyzed for radioactivity. No evidence for the transplacental transfer of [14C]Carmoisine or its metabolites was obtained. More than 90% of the radioactivity was excreted in feces and urine within 64 h. Â© 1982.
Placental transfer and tissue localization of [14C]carmoisine in the pregnant rat / Galli, C. L.; Marinovich, M.; Costa, L. G.; Giavini, E.. - In: TOXICOLOGY LETTERS. - ISSN 0378-4274. - 10:2-3(1982), pp. 255-258. [10.1016/0378-4274(82)90084-4]
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