Male mice administered neostigmine in the drinking water at daily increasing concentrations (20-1000 mg/l) for four days became tolerant to its toxicity and presented a reduced binding of [3H]quinuclidinyl benzilate ([3H]QNB) in the small intestine. An increased binding of [3H]QNB was found in the forebrains of neostigmine-treated animals. This was due to an increase in muscarinic cholinergic receptor density. Neostigmine-treated animals were also more sensitive than control to the hypothermic effect induced by oxotremorine. Dopaminergic and α- and β-adrenoceptors were not affected. Administration of methylatropine together with neostigmine prevented the decrease of [3H]QNB binding in the small intestine as well as the increase in the forebrain. © 1982.
Muscarinic receptor alterations following neostigmine treatment / Costa, Lucio G.; Schwab, Bradley W.; Murphy, Sheldon D.. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 80:2-3(1982), pp. 275-278. [10.1016/0014-2999(82)90069-3]
Muscarinic receptor alterations following neostigmine treatment
Costa, Lucio G.;
1982-01-01
Abstract
Male mice administered neostigmine in the drinking water at daily increasing concentrations (20-1000 mg/l) for four days became tolerant to its toxicity and presented a reduced binding of [3H]quinuclidinyl benzilate ([3H]QNB) in the small intestine. An increased binding of [3H]QNB was found in the forebrains of neostigmine-treated animals. This was due to an increase in muscarinic cholinergic receptor density. Neostigmine-treated animals were also more sensitive than control to the hypothermic effect induced by oxotremorine. Dopaminergic and α- and β-adrenoceptors were not affected. Administration of methylatropine together with neostigmine prevented the decrease of [3H]QNB binding in the small intestine as well as the increase in the forebrain. © 1982.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
