The effect of trimethyltin (TMT; 4.26 mg/kg i.p.), at 1 and 14 hr following administration, on chemically-induced seizures in mice is reported. At 1 hr following administration, TMT decreased seizure responsiveness and protected animals from bicuculline, isonicotinic acid hydrazide (INH) and pentylenetetrazol (PTZ) induced seizures. At 14 hr following administration, TMT provided little protection against bicuculline, INH or PTZ induced seizures. Only slight decreases in seizure responsiveness were observed with strychnine induced seizures at either 1 or 14 hr. By 16 hr following administration, animals exhibited spontaneous tremors and convulsions. The results indicate that TMT exerts a biphasic effect on central nervous system excitability.
Effect of trimethyltin on chemically-induced seizures / Doctor, S. V.; Costa, L. G.; Murphy, S. D.. - In: TOXICOLOGY LETTERS. - ISSN 0378-4274. - 13:3-4(1982), pp. 217-223.
Effect of trimethyltin on chemically-induced seizures
Costa, L. G.;
1982-01-01
Abstract
The effect of trimethyltin (TMT; 4.26 mg/kg i.p.), at 1 and 14 hr following administration, on chemically-induced seizures in mice is reported. At 1 hr following administration, TMT decreased seizure responsiveness and protected animals from bicuculline, isonicotinic acid hydrazide (INH) and pentylenetetrazol (PTZ) induced seizures. At 14 hr following administration, TMT provided little protection against bicuculline, INH or PTZ induced seizures. Only slight decreases in seizure responsiveness were observed with strychnine induced seizures at either 1 or 14 hr. By 16 hr following administration, animals exhibited spontaneous tremors and convulsions. The results indicate that TMT exerts a biphasic effect on central nervous system excitability.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
