Background Interventions including physical exercise may help improve the outcomes of late-life major depression, but few studies are available. Aims To investigate whether augmenting sertraline therapy with physical exercise leads to better outcomes of late-life major depression. Method Primary care patients (465 years) with major depression were randomised to 24 weeks of higher-intensity, progressive aerobic exercise plus sertraline (S+PAE), lowerintensity, non-progressive exercise plus sertraline (S+NPE) and sertraline alone. The primary outcome was remission (a score of 410 on the Hamilton Rating Scale for Depression). Results A total of 121 patients were included. At study end, 45% of participants in the sertraline group, 73% of those in the S+NPE group and 81% of those in the S+PAE group achieved remission (P = 0.001). A shorter time to remission was observed in the S+PAE group than in the sertraline-only group. Conclusions Physical exercise may be a safe and effective augmentation to antidepressant therapy in late-life major depression.
Physical exercise for late-life major depression / Belvederi Murri, M., Amore, M., Menchetti, M., Toni, G., Neviani, F., Cerri, M., Rocchi, M.B.L., Zocchi, D., Bagnoli, L., Tam, E., Buffa, A., Ferrara, S., Neri, M., Alexopoulos, G.S., Zanetidou, S., di Meana, F.r., Marcaccio, M.l., Argnani, P., Fioritti, A., Morini, M., et al.. - In: BRITISH JOURNAL OF PSYCHIATRY. - ISSN 0007-1250. - 207:3(2015), pp. 235-242. [10.1192/bjp.bp.114.150516]
Physical exercise for late-life major depression
Belvederi Murri, M.;Amore, M.;Toni, G.;Cerri, M.;BUFFA, ANNALISA;CASINI, FRANCESCA;Piras A;Chiesa R;Ceresini G;Cabassi A;Gerra M.L.
2015-01-01
Abstract
Background Interventions including physical exercise may help improve the outcomes of late-life major depression, but few studies are available. Aims To investigate whether augmenting sertraline therapy with physical exercise leads to better outcomes of late-life major depression. Method Primary care patients (465 years) with major depression were randomised to 24 weeks of higher-intensity, progressive aerobic exercise plus sertraline (S+PAE), lowerintensity, non-progressive exercise plus sertraline (S+NPE) and sertraline alone. The primary outcome was remission (a score of 410 on the Hamilton Rating Scale for Depression). Results A total of 121 patients were included. At study end, 45% of participants in the sertraline group, 73% of those in the S+NPE group and 81% of those in the S+PAE group achieved remission (P = 0.001). A shorter time to remission was observed in the S+PAE group than in the sertraline-only group. Conclusions Physical exercise may be a safe and effective augmentation to antidepressant therapy in late-life major depression.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
