Background Interventions including physical exercise may help improve the outcomes of late-life major depression, but few studies are available. Aims To investigate whether augmenting sertraline therapy with physical exercise leads to better outcomes of late-life major depression. Method Primary care patients (465 years) with major depression were randomised to 24 weeks of higher-intensity, progressive aerobic exercise plus sertraline (S+PAE), lowerintensity, non-progressive exercise plus sertraline (S+NPE) and sertraline alone. The primary outcome was remission (a score of 410 on the Hamilton Rating Scale for Depression). Results A total of 121 patients were included. At study end, 45% of participants in the sertraline group, 73% of those in the S+NPE group and 81% of those in the S+PAE group achieved remission (P = 0.001). A shorter time to remission was observed in the S+PAE group than in the sertraline-only group. Conclusions Physical exercise may be a safe and effective augmentation to antidepressant therapy in late-life major depression.
Physical exercise for late-life major depression / Belvederi Murri, M.; Amore, M.; Menchetti, M.; Toni, G.; Neviani, F.; Cerri, M.; Rocchi, M. B. L.; Zocchi, D.; Bagnoli, L.; Tam, E.; Buffa, A.; Ferrara, S.; Neri, M.; Alexopoulos, G. S.; Zanetidou, S.; di Meana, Fr; Marcaccio, Ml; Argnani, P; Fioritti, A; Morini, M; Trevisani, F; Squatrito, S; Senaldi, R; De Girolamo, G; Di Diodoro, D; Neri, G; Spezia, C; Magagnoli, M; Luciano, C; Casini, F; Ermini, G; Casarini, P; Bardazzi, V; Piras, A; Tola, G; Rizzo, R; De Bei, L; Comastri, D; Tripi, F; Mannina, M; Piepoli, M; Zoboli, S; Torcianti, G; Colombini, N; Guido, F; Ferrari, S; Pellati, M; Silva, Vb; Cepelli, A; Francia, E; Chiesa, R; Frignani, Ag; Montegano, C; Ceresini, G; Montali, A; Cabassi, A; Masotti, M; Gerra, M. L.. - In: BRITISH JOURNAL OF PSYCHIATRY. - ISSN 0007-1250. - 207:3(2015), pp. 235-242. [10.1192/bjp.bp.114.150516]
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