OBJECTIVES: We described clinical–epidemiological features of prosthetic valve endocarditis (PVE) and assessed the determinants of early surgical outcomes in multicentre design. METHODS: Data regarding 2823 patients undergoing surgery for endocarditis at 19 Italian Centers between 1979 and 2015 were collected in a database. Of them, 582 had PVE: in this group, the determinants of early mortality and complications were assessed, also taking into account the different chronological eras encompassed by the study. RESULTS: Overall hospital (30-day) mortality was 19.2% (112 patients). Postoperative complications of any type occurred in 256 patients (44%). Across 3 eras (1980–2000, 2001–08 and 2009–14), early mortality did not significantly change (20.4%, 17.1%, 20.5%, respectively, P = 0.60), whereas complication rate increased (18.5%, 38.2%, 52.8%, P < 0.001), consistent with increasing mean patient age (56 ± 14, 64 ± 15, 65 ± 14 years, respectively, P < 0.001) and median logistic EuroSCORE (14%, 21%, 23%, P = 0.025). Older age, female sex, preoperative serum creatinine >-2 mg/dl, chronic pulmonary disease, low ejection fraction, non-streptococcal aetiology, active endocarditis, preoperative intubation, preoperative shock and triple valve surgery were significantly associated with mortality. In multivariable analysis, age (OR = 1.02; P = 0.03), renal insufficiency (OR = 2.1; P = 0.05), triple valve surgery (OR = 6.9; P = 0.004) and shock (OR = 4.5; P < 0.001) were independently associated with mortality, while streptococcal aetiology, healed endocarditis and ejection fraction with survival. Adjusting for study era, preoperative shock (OR = 3; P < 0.001), Enterococcus (OR = 2.3; P = 0.01) and female sex (OR = 1.5; P = 0.03) independently predicted complications, whereas ejection fraction was protective. CONCLUSIONS: PVE surgery remains a high-risk one. The strongest predictors of early outcome of PVE surgery are related to patient’s haemodynamic status and microbiological factors.

Surgery for prosthetic valve endocarditis: a retrospective study of a national registry† / Della Corte, Alessandro; Dimauro, Michele; Dato, Guglielmo Actis; Barili, Fabio; Cugola, Diego; Gelsomino, Sandro; Sante, Pasquale; Carozza, Antonio; Ratta, Ester Della; Galletti, Lorenzo; Devotini, Roger; Casabona, Riccardo; Santini, Francesco; Salsano, Antonio; Scrofani, Roberto; Antona, Carlo; Vincentiis, Carlo De; Biondi, Andrea; Beghi, Cesare; Cappabianca, Giangiuseppe; Bonis, Michele De; Pozzoli, Alberto; Nicolini, Francesco; Benassi, Filippo; Pacini, Davide; Bartolomeo, Roberto Di; Demartino, Andrea; Bortolotti, Uberto; Lorusso, Roberto; Vizzardi, Enrico; Giammarco, Gabriele Di; Danielemarinelli, ; Villa, Emmanuel; Troise, Giovanni; Paparella, Domenico; Vitomargari, ; Tritto, Francesco; Damiani, Girolamo; Scrascia, Giuseppe; Zaccaria, Salvatore; Renzulli, Attilio; Serraino, Giuseppe; Mariscalco, Giovanni; Maselli, Daniele; Parolari, Alessandro; Nappi, Giannantonio. - In: EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY. - ISSN 1010-7940. - 52:1(2017), pp. 105-111. [10.1093/ejcts/ezx045]

Surgery for prosthetic valve endocarditis: a retrospective study of a national registry†.

NICOLINI, Francesco;
2017-01-01

Abstract

OBJECTIVES: We described clinical–epidemiological features of prosthetic valve endocarditis (PVE) and assessed the determinants of early surgical outcomes in multicentre design. METHODS: Data regarding 2823 patients undergoing surgery for endocarditis at 19 Italian Centers between 1979 and 2015 were collected in a database. Of them, 582 had PVE: in this group, the determinants of early mortality and complications were assessed, also taking into account the different chronological eras encompassed by the study. RESULTS: Overall hospital (30-day) mortality was 19.2% (112 patients). Postoperative complications of any type occurred in 256 patients (44%). Across 3 eras (1980–2000, 2001–08 and 2009–14), early mortality did not significantly change (20.4%, 17.1%, 20.5%, respectively, P = 0.60), whereas complication rate increased (18.5%, 38.2%, 52.8%, P < 0.001), consistent with increasing mean patient age (56 ± 14, 64 ± 15, 65 ± 14 years, respectively, P < 0.001) and median logistic EuroSCORE (14%, 21%, 23%, P = 0.025). Older age, female sex, preoperative serum creatinine >-2 mg/dl, chronic pulmonary disease, low ejection fraction, non-streptococcal aetiology, active endocarditis, preoperative intubation, preoperative shock and triple valve surgery were significantly associated with mortality. In multivariable analysis, age (OR = 1.02; P = 0.03), renal insufficiency (OR = 2.1; P = 0.05), triple valve surgery (OR = 6.9; P = 0.004) and shock (OR = 4.5; P < 0.001) were independently associated with mortality, while streptococcal aetiology, healed endocarditis and ejection fraction with survival. Adjusting for study era, preoperative shock (OR = 3; P < 0.001), Enterococcus (OR = 2.3; P = 0.01) and female sex (OR = 1.5; P = 0.03) independently predicted complications, whereas ejection fraction was protective. CONCLUSIONS: PVE surgery remains a high-risk one. The strongest predictors of early outcome of PVE surgery are related to patient’s haemodynamic status and microbiological factors.
2017
Surgery for prosthetic valve endocarditis: a retrospective study of a national registry† / Della Corte, Alessandro; Dimauro, Michele; Dato, Guglielmo Actis; Barili, Fabio; Cugola, Diego; Gelsomino, Sandro; Sante, Pasquale; Carozza, Antonio; Ratta, Ester Della; Galletti, Lorenzo; Devotini, Roger; Casabona, Riccardo; Santini, Francesco; Salsano, Antonio; Scrofani, Roberto; Antona, Carlo; Vincentiis, Carlo De; Biondi, Andrea; Beghi, Cesare; Cappabianca, Giangiuseppe; Bonis, Michele De; Pozzoli, Alberto; Nicolini, Francesco; Benassi, Filippo; Pacini, Davide; Bartolomeo, Roberto Di; Demartino, Andrea; Bortolotti, Uberto; Lorusso, Roberto; Vizzardi, Enrico; Giammarco, Gabriele Di; Danielemarinelli, ; Villa, Emmanuel; Troise, Giovanni; Paparella, Domenico; Vitomargari, ; Tritto, Francesco; Damiani, Girolamo; Scrascia, Giuseppe; Zaccaria, Salvatore; Renzulli, Attilio; Serraino, Giuseppe; Mariscalco, Giovanni; Maselli, Daniele; Parolari, Alessandro; Nappi, Giannantonio. - In: EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY. - ISSN 1010-7940. - 52:1(2017), pp. 105-111. [10.1093/ejcts/ezx045]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2835971
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