Osteoclasts, the cells that resorb bone, develop from hematopoietic precursors of the bone marrow under the control of factors produced in their microenvironment. The cytokine interleukin-6 can promote hematopoiesis and osteoclastogenesis. Interleukin-6 production by bone and marrow stromal cells is suppressed by 17Î²-estradiol in vitro. In mice, estrogen loss (ovariectomy) increased the number of colony-forming units for granulocytes and macrophages, enhanced osteoclast development in ex vivo cultures of marrow, and increased the number of osteoclasts in trabecular bone. These changes were prevented by 17Î²-estradiol or an antibody to interleukin-6. Thus, estrogen loss results in an interleukin-6-mediated stimulation of osteoclastogenesis, which suggests a mechanism for the increased bone resorption in postmenopausal osteoporosis.
Increased osteoclast development after estrogen loss: Mediation by interleukin-6 / Jilka, Robert L.; Hangoc, Giao; Girasole, Giuseppe; Passeri, Giovanni; Williams, Daniel C.; Abrams, John S.; Boyce, Brendan; Broxmeyer, Hal; Manolagas, Stavros C.. - In: SCIENCE. - ISSN 0036-8075. - 257:5066(1992), pp. 88-91.
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