After having been extensively studied as a receptor for small guests (both neutral and charged), the last 20 years have witnessed the progressive use of the calixarene macrocycle as a ligand for the recognition of large biomacromolecules. Thanks to the easy functionalization of both rims, to the multivalent nature of the scaffold, and to the possibility of controlling its three-dimensional shape and conformation, a number of calixarene derivatives able to selectively interact with proteins (including specific areas of a protein surface or an active site) or with nucleic acids have been reported. This review critically covers the results obtained in the field of biomacromolecule recognition by calixarene derivatives, giving a special emphasis to those examples where the interaction with the target leads to a specific and potentially medically relevant activity, such as protein inhibition, disruption of protein-protein interactions, and gene delivery.

Biomacromolecule Recognition by Calixarene Macrocycles / Baldini, Laura; Casnati, Alessandro; Sansone, Francesco. - STAMPA. - 4(2017), pp. 371-408. [10.1016/B978-0-12-409547-2.12545-4]

Biomacromolecule Recognition by Calixarene Macrocycles.

BALDINI, Laura;CASNATI, Alessandro;SANSONE, Francesco
2017

Abstract

After having been extensively studied as a receptor for small guests (both neutral and charged), the last 20 years have witnessed the progressive use of the calixarene macrocycle as a ligand for the recognition of large biomacromolecules. Thanks to the easy functionalization of both rims, to the multivalent nature of the scaffold, and to the possibility of controlling its three-dimensional shape and conformation, a number of calixarene derivatives able to selectively interact with proteins (including specific areas of a protein surface or an active site) or with nucleic acids have been reported. This review critically covers the results obtained in the field of biomacromolecule recognition by calixarene derivatives, giving a special emphasis to those examples where the interaction with the target leads to a specific and potentially medically relevant activity, such as protein inhibition, disruption of protein-protein interactions, and gene delivery.
9780128031988
Biomacromolecule Recognition by Calixarene Macrocycles / Baldini, Laura; Casnati, Alessandro; Sansone, Francesco. - STAMPA. - 4(2017), pp. 371-408. [10.1016/B978-0-12-409547-2.12545-4]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2830587
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