Background: There is a need for validated tools to assess health-related quality of life (HRQoL) in routine clinical practice. Objective: The aim of this study was to validate the Chronic Urticaria Patient Perspective (CUPP) for assessment of patients with chronic urticaria (CU) in clinical practice. Methods: A provisional CUPP was developed from candidate items identified by following an iterative process in a retrospective analysis of 249 Chronic Urticaria Quality of Life Questionnaire questionnaires. The psychometric properties of the CUPP were then tested on a sample of patients enrolled in 13 Italian centers. Results: The study population in the validation phase comprised 152 patients. The 10-item version of the CUPP showed satisfactory internal consistency (Cronbach's alpha values of 0.76 at visit 1 and 0.90 at visit 2), good criteria, and discriminative and convergent validity. Reliability was assessed in 34 patients with no changes in health (Global Rating Scale = 0 at visit 2) and was satisfactory (CCC [concordance correlation coefficient] = 0.9). Changes in CUPP scores were significantly associated with changes in Urticaria Activity Score (UAS)-Hive count (r = 0.36, P < .001), UAS-Itch severity (r = 0.48, P < .001), and UAS-Total score (r = 0.342, P < .001), all of which indicated good responsiveness. The minimal important difference was 1.5. Conclusions: CUPP is a simple 10-question tool with good psychometric properties that provides a valid, reliable, and standardized measurement of HRQoL in patients with CU.

Chronic Urticaria Patient Perspective (CUPP): The First Validated Tool for Assessing Quality of Life in Clinical Practice / Baiardini, Ilaria; Braido, Fulvio; Molinengo, Giorgia; Caminati, Marco; Costantino, Mariateresa; Cristaudo, Antonio; Crivellaro, Mariangiola; Ferrucci, Silvia Mariel; Gallo, Rosella; Giorgis, Veronica; Legori, Agostina; Loera, Barbara; Martignago, Irene; Marzano, Angelo Valerio; Morrone, Aldo; Parente, Roberta; Parodi, Aurora; Parolo, Anna; Peveri, Silvia; Pigatto, Paolo; Radice, Anna; Ridolo, Erminia; Rolla, Giovanni; Roncallo, Chiara; Rossi, Oliviero; Savi, Eleonora; Senna, Gianenrico; Triggiani, Massimo; Canonica, Giorgio Walter. - In: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. IN PRACTICE. - ISSN 2213-2198. - 6:1(2018), pp. 208-218. [10.1016/j.jaip.2017.06.023]

Chronic Urticaria Patient Perspective (CUPP): The First Validated Tool for Assessing Quality of Life in Clinical Practice

MARTIGNAGO, IRENE;RIDOLO, Erminia;
2018-01-01

Abstract

Background: There is a need for validated tools to assess health-related quality of life (HRQoL) in routine clinical practice. Objective: The aim of this study was to validate the Chronic Urticaria Patient Perspective (CUPP) for assessment of patients with chronic urticaria (CU) in clinical practice. Methods: A provisional CUPP was developed from candidate items identified by following an iterative process in a retrospective analysis of 249 Chronic Urticaria Quality of Life Questionnaire questionnaires. The psychometric properties of the CUPP were then tested on a sample of patients enrolled in 13 Italian centers. Results: The study population in the validation phase comprised 152 patients. The 10-item version of the CUPP showed satisfactory internal consistency (Cronbach's alpha values of 0.76 at visit 1 and 0.90 at visit 2), good criteria, and discriminative and convergent validity. Reliability was assessed in 34 patients with no changes in health (Global Rating Scale = 0 at visit 2) and was satisfactory (CCC [concordance correlation coefficient] = 0.9). Changes in CUPP scores were significantly associated with changes in Urticaria Activity Score (UAS)-Hive count (r = 0.36, P < .001), UAS-Itch severity (r = 0.48, P < .001), and UAS-Total score (r = 0.342, P < .001), all of which indicated good responsiveness. The minimal important difference was 1.5. Conclusions: CUPP is a simple 10-question tool with good psychometric properties that provides a valid, reliable, and standardized measurement of HRQoL in patients with CU.
2018
Chronic Urticaria Patient Perspective (CUPP): The First Validated Tool for Assessing Quality of Life in Clinical Practice / Baiardini, Ilaria; Braido, Fulvio; Molinengo, Giorgia; Caminati, Marco; Costantino, Mariateresa; Cristaudo, Antonio; Crivellaro, Mariangiola; Ferrucci, Silvia Mariel; Gallo, Rosella; Giorgis, Veronica; Legori, Agostina; Loera, Barbara; Martignago, Irene; Marzano, Angelo Valerio; Morrone, Aldo; Parente, Roberta; Parodi, Aurora; Parolo, Anna; Peveri, Silvia; Pigatto, Paolo; Radice, Anna; Ridolo, Erminia; Rolla, Giovanni; Roncallo, Chiara; Rossi, Oliviero; Savi, Eleonora; Senna, Gianenrico; Triggiani, Massimo; Canonica, Giorgio Walter. - In: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. IN PRACTICE. - ISSN 2213-2198. - 6:1(2018), pp. 208-218. [10.1016/j.jaip.2017.06.023]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2829567
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