ABSTRACT This case report refers to ovarian metastases from Renal Clear cell Carcinoma (RCC) in a 46-year-old woman with a history of abdominal pain and urinary incontinence. A pelvic ultrasound revealed a heterogeneous, large, right-sided solid/multi-cystic ovarian mass, suggesting diagnosis of borderline or malignant epithelial ovarian tumor. At staging, abdominal Computed Tomography (CT) incidentally revealed an enlarged left kidney with a lesion, consistent with renal carcinoma. At the time of surgery, a frozen section of ovarian neoplasm was performed to confirm diagnosis of primary epithelial borderline ovarian tumor or metastatic renal carcinoma. Macroscopically, the right ovary had been entirely replaced by a multiloculated cystic lesion with clear serous fluid, solid septa, and centrally, a solid gray area. Imprint cytology, performed during an intra-operative study of the lesion, showed cohesive clusters of neoplastic cells with clear abundant and vacuolated cytoplasm, pleomorphic, medium or large nuclei and evident nucleoli. Histological examination revealed an epithelial neoplasms, characterized by large cells with clear optically empty cytoplasm that lined the alveolar and cystic spaces. A prominent vascular component with sinusoidal features was also present. These findings and the clinical data of the simultaneous renal lesion were consistent with an intra-operative diagnosis of ovarian metastatic renal carcinoma. Permanent sections revealed that the ovarian lesion showed the same pathological features as those observed in frozen sections. Immunohistochemical analysis of the ovarian tumor showing positivity for CD10 and Renal Clear Cell Marker (RCC Ma), while the presence of RCC in a nephrectomy specimen confirmed ovarian metastatic renal carcinoma. In conclusion, although ovarian metastasis of RCC is very rare, diagnosis can be made by careful histological examination, immunohistochemical study, plus clinical data

Ovarian metastasis from renal clear cell carcinoma: A case report with an intra-operative, immunohistochemical study and a review of the literature / Giordano, Giovanna; Pezzuto, A; Silini, Enrico Maria. - In: EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY. - ISSN 0392-2936. - XXXIX:6(2018), pp. 1022-1027. [10.12892/ejgo4194.2018]

Ovarian metastasis from renal clear cell carcinoma: A case report with an intra-operative, immunohistochemical study and a review of the literature

GIORDANO, Giovanna;Pezzuto, A;SILINI, Enrico Maria
2018-01-01

Abstract

ABSTRACT This case report refers to ovarian metastases from Renal Clear cell Carcinoma (RCC) in a 46-year-old woman with a history of abdominal pain and urinary incontinence. A pelvic ultrasound revealed a heterogeneous, large, right-sided solid/multi-cystic ovarian mass, suggesting diagnosis of borderline or malignant epithelial ovarian tumor. At staging, abdominal Computed Tomography (CT) incidentally revealed an enlarged left kidney with a lesion, consistent with renal carcinoma. At the time of surgery, a frozen section of ovarian neoplasm was performed to confirm diagnosis of primary epithelial borderline ovarian tumor or metastatic renal carcinoma. Macroscopically, the right ovary had been entirely replaced by a multiloculated cystic lesion with clear serous fluid, solid septa, and centrally, a solid gray area. Imprint cytology, performed during an intra-operative study of the lesion, showed cohesive clusters of neoplastic cells with clear abundant and vacuolated cytoplasm, pleomorphic, medium or large nuclei and evident nucleoli. Histological examination revealed an epithelial neoplasms, characterized by large cells with clear optically empty cytoplasm that lined the alveolar and cystic spaces. A prominent vascular component with sinusoidal features was also present. These findings and the clinical data of the simultaneous renal lesion were consistent with an intra-operative diagnosis of ovarian metastatic renal carcinoma. Permanent sections revealed that the ovarian lesion showed the same pathological features as those observed in frozen sections. Immunohistochemical analysis of the ovarian tumor showing positivity for CD10 and Renal Clear Cell Marker (RCC Ma), while the presence of RCC in a nephrectomy specimen confirmed ovarian metastatic renal carcinoma. In conclusion, although ovarian metastasis of RCC is very rare, diagnosis can be made by careful histological examination, immunohistochemical study, plus clinical data
2018
Ovarian metastasis from renal clear cell carcinoma: A case report with an intra-operative, immunohistochemical study and a review of the literature / Giordano, Giovanna; Pezzuto, A; Silini, Enrico Maria. - In: EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY. - ISSN 0392-2936. - XXXIX:6(2018), pp. 1022-1027. [10.12892/ejgo4194.2018]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2829414
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