Aims: Individuals with type 2 diabetes show shorter leukocyte telomere length (LTL) compared to people without diabetes. Reduced LTL is associated with increased carotid intima-media thickness (IMT) in healthy subjects. The aim of the study is to assess whether LTL also correlates with IMT in patients with diabetes. Methods: In a cohort of 104 subjects with type 2 diabetes and atherogenic dyslipidemia, we assessed anthropometric, hemodynamic and metabolic parameters. Common carotid IMT was expressed as the maximum IMT. LTL was assessed by a specific real-time PCR reaction. Results: At univariate analysis, IMT values were positively correlated with age (p < 0.001), previous history of cardiovascular events (p < 0.005), fasting plasma glucose (p < 0.01), HbA1c (p < 0.05) and negatively correlated with LTL (p < 0.05). In a multivariate model, age (p < 0.001) and LTL (p < 0.05) were the only independent predictors of maximum IMT, with an adjusted R2 of 0.22. Conclusions: LTL is an independent predictor of subclinical atherosclerosis pointing to a role of LTL as an early marker of vascular burden and cardiovascular disease also in type 2 diabetes.

Telomere length is independently associated with subclinical atherosclerosis in subjects with type 2 diabetes: a cross-sectional study / Spigoni, Valentina; Aldigeri, Raffaella; Picconi, Angela; Derlindati, Eleonora; Franzini, Laura; Haddoub, Silvia; Prampolini, Giorgia; Vigna, Giovanni B.; Zavaroni, Ivana; Bonadonna, Riccardo; DEI CAS, Alessandra. - In: ACTA DIABETOLOGICA. - ISSN 0940-5429. - 53:4(2016), pp. 661-667. [10.1007/s00592-016-0857-x]

Telomere length is independently associated with subclinical atherosclerosis in subjects with type 2 diabetes: a cross-sectional study

SPIGONI, Valentina;ALDIGERI, Raffaella;PICCONI, Angela;DERLINDATI, Eleonora;FRANZINI, Laura;HADDOUB, Silvia;PRAMPOLINI, Giorgia;ZAVARONI, Ivana;BONADONNA, Riccardo;DEI CAS, Alessandra
2016-01-01

Abstract

Aims: Individuals with type 2 diabetes show shorter leukocyte telomere length (LTL) compared to people without diabetes. Reduced LTL is associated with increased carotid intima-media thickness (IMT) in healthy subjects. The aim of the study is to assess whether LTL also correlates with IMT in patients with diabetes. Methods: In a cohort of 104 subjects with type 2 diabetes and atherogenic dyslipidemia, we assessed anthropometric, hemodynamic and metabolic parameters. Common carotid IMT was expressed as the maximum IMT. LTL was assessed by a specific real-time PCR reaction. Results: At univariate analysis, IMT values were positively correlated with age (p < 0.001), previous history of cardiovascular events (p < 0.005), fasting plasma glucose (p < 0.01), HbA1c (p < 0.05) and negatively correlated with LTL (p < 0.05). In a multivariate model, age (p < 0.001) and LTL (p < 0.05) were the only independent predictors of maximum IMT, with an adjusted R2 of 0.22. Conclusions: LTL is an independent predictor of subclinical atherosclerosis pointing to a role of LTL as an early marker of vascular burden and cardiovascular disease also in type 2 diabetes.
Telomere length is independently associated with subclinical atherosclerosis in subjects with type 2 diabetes: a cross-sectional study / Spigoni, Valentina; Aldigeri, Raffaella; Picconi, Angela; Derlindati, Eleonora; Franzini, Laura; Haddoub, Silvia; Prampolini, Giorgia; Vigna, Giovanni B.; Zavaroni, Ivana; Bonadonna, Riccardo; DEI CAS, Alessandra. - In: ACTA DIABETOLOGICA. - ISSN 0940-5429. - 53:4(2016), pp. 661-667. [10.1007/s00592-016-0857-x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2826039
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