Advances in interfacing liquid chromatography and electron ionization mass spectrometry are presented. New ion source coatings synthesized by sol-gel technology were developed and tested as vaporization surfaces in terms of peak intensity, peak width and peak delay for the liquid chromatography-direct electron ionization mass spectrometry (Direct-EI) determination of environmental pollutants like polycyclic aromatic hydrocarbons and steroids. Silica-, titania-, and zirconia-based coatings were sprayed inside the stainless steel ion source and characterized in terms of thermal stability, film thickness and morphology. Negligible weight losses until 350–400 °C were observed for all the materials, with coating thicknesses in the 6 (±1)-11 (±2) μm range for optimal ionization process. The best performances in terms of both peak intensity and peak width were obtained by using the silica-based coating: the detection of the investigated compounds was feasible at low ng μl−1 levels with a good precision (RSD < 9% for polycyclic aromatic hydrocarbons and <11% for hormones).

Sol-gel coated ion sources for liquid chromatography-direct electron ionization mass spectrometry / Riboni, Nicolo'; Magrini, Laura; Bianchi, Federica; Careri, Maria; Cappiello, Achille. - In: ANALYTICA CHIMICA ACTA. - ISSN 0003-2670. - 978:(2017), pp. 35-41. [10.1016/j.aca.2017.04.026]

Sol-gel coated ion sources for liquid chromatography-direct electron ionization mass spectrometry

RIBONI, NICOLO';BIANCHI, Federica;CARERI, Maria;CAPPIELLO, ACHILLE
2017

Abstract

Advances in interfacing liquid chromatography and electron ionization mass spectrometry are presented. New ion source coatings synthesized by sol-gel technology were developed and tested as vaporization surfaces in terms of peak intensity, peak width and peak delay for the liquid chromatography-direct electron ionization mass spectrometry (Direct-EI) determination of environmental pollutants like polycyclic aromatic hydrocarbons and steroids. Silica-, titania-, and zirconia-based coatings were sprayed inside the stainless steel ion source and characterized in terms of thermal stability, film thickness and morphology. Negligible weight losses until 350–400 °C were observed for all the materials, with coating thicknesses in the 6 (±1)-11 (±2) μm range for optimal ionization process. The best performances in terms of both peak intensity and peak width were obtained by using the silica-based coating: the detection of the investigated compounds was feasible at low ng μl−1 levels with a good precision (RSD < 9% for polycyclic aromatic hydrocarbons and <11% for hormones).
Sol-gel coated ion sources for liquid chromatography-direct electron ionization mass spectrometry / Riboni, Nicolo'; Magrini, Laura; Bianchi, Federica; Careri, Maria; Cappiello, Achille. - In: ANALYTICA CHIMICA ACTA. - ISSN 0003-2670. - 978:(2017), pp. 35-41. [10.1016/j.aca.2017.04.026]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2825504
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