Aflatoxins represent a serious problem for a food economy based on cereal cultivations used to fodder animal and for human nutrition. The aims of our work are two-fold: first, to perform an evaluation of the activity of newly synthesized thiosemicarbazone compounds as antifungal and anti-mycotoxin agents and, second, to conduct studies on the toxic and genotoxic hazard potentials with a battery of tests with different endpoints. In this paper we report an initial study on two molecules: S-4-isopropenylcyclohexen-1-carbaldehydethiosemicarbazone and its metal complex, bis(S-4-isopropenylcyclohexen-1-carbaldehydethiosemicarbazonato)nickel (II). The outcome of the assays on fungi growth and aflatoxin production inhibition show that both molecules possess good antifungal activities, without inducing mutagenic effects on bacteria. From the assays to ascertain that the compounds have no adverse effects on human cells, we have found that they are cytotoxic and, in the case of the nickel compound, they also present genotoxic effects.

A battery of assays as an integrated approach to evaluate fungal and mycotoxin inhibition properties and cytotoxic/genotoxic side-effects for the prioritization in the screening of thiosemicarbazone derivatives / Zani, Claudia; Bisceglie, Franco; Restivo, Francesco Maria; Feretti, Donatella; Pioli, Marianna; Degola, Francesca; Montalbano, Serena; Galati, Serena; Pelosi, Giorgio; Viola, Gaia V. C; Carcelli, Mauro; Rogolino, Dominga; Ceretti, Elisabetta; Buschini, Annamaria. - In: FOOD AND CHEMICAL TOXICOLOGY. - ISSN 0278-6915. - 105:(2017), pp. 498-505. [10.1016/j.fct.2017.05.008]

A battery of assays as an integrated approach to evaluate fungal and mycotoxin inhibition properties and cytotoxic/genotoxic side-effects for the prioritization in the screening of thiosemicarbazone derivatives

BISCEGLIE, Franco;RESTIVO, Francesco Maria;PIOLI, MARIANNA;DEGOLA, Francesca;MONTALBANO, SERENA;GALATI, Serena;PELOSI, Giorgio;CARCELLI, Mauro;ROGOLINO, Dominga;BUSCHINI, Annamaria
2017-01-01

Abstract

Aflatoxins represent a serious problem for a food economy based on cereal cultivations used to fodder animal and for human nutrition. The aims of our work are two-fold: first, to perform an evaluation of the activity of newly synthesized thiosemicarbazone compounds as antifungal and anti-mycotoxin agents and, second, to conduct studies on the toxic and genotoxic hazard potentials with a battery of tests with different endpoints. In this paper we report an initial study on two molecules: S-4-isopropenylcyclohexen-1-carbaldehydethiosemicarbazone and its metal complex, bis(S-4-isopropenylcyclohexen-1-carbaldehydethiosemicarbazonato)nickel (II). The outcome of the assays on fungi growth and aflatoxin production inhibition show that both molecules possess good antifungal activities, without inducing mutagenic effects on bacteria. From the assays to ascertain that the compounds have no adverse effects on human cells, we have found that they are cytotoxic and, in the case of the nickel compound, they also present genotoxic effects.
2017
A battery of assays as an integrated approach to evaluate fungal and mycotoxin inhibition properties and cytotoxic/genotoxic side-effects for the prioritization in the screening of thiosemicarbazone derivatives / Zani, Claudia; Bisceglie, Franco; Restivo, Francesco Maria; Feretti, Donatella; Pioli, Marianna; Degola, Francesca; Montalbano, Serena; Galati, Serena; Pelosi, Giorgio; Viola, Gaia V. C; Carcelli, Mauro; Rogolino, Dominga; Ceretti, Elisabetta; Buschini, Annamaria. - In: FOOD AND CHEMICAL TOXICOLOGY. - ISSN 0278-6915. - 105:(2017), pp. 498-505. [10.1016/j.fct.2017.05.008]
File in questo prodotto:
File Dimensione Formato  
Pre-print Food chem toxicol.pdf

accesso aperto

Descrizione: Articolo principale
Tipologia: Documento in Pre-print
Licenza: Creative commons
Dimensione 821.83 kB
Formato Adobe PDF
821.83 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2823681
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 12
social impact