Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance. It is important to identify factors associated with these different mechanisms to optimize control measures. We conducted a prospective cohort study of index TB patients and their household contacts in Lima, Peru to identify risk factors associated with acquired and transmitted resistance, respectively. Patients with higher socioeconomic status (SES) had a 3-fold increased risk of transmitted resistance compared to those with lower SES when acquired resistance served as the baseline. Quality of housing mediated most of the impact of SES.

Acquired and transmitted multidrug resistant tuberculosis: The role of social determinants / Odone, Anna; Calderon, Roger; Becerra, Mercedes C.; Zhang, Zibiao; Contreras, Carmen C.; Yataco, Rosa; Galea, Jerome; Lecca, Leonid; Bonds, Matthew H.; Mitnick, Carole D.; Murray, Megan B.. - In: PLOS ONE. - ISSN 1932-6203. - 11:1(2016), p. e0146642. [10.1371/journal.pone.0146642]

Acquired and transmitted multidrug resistant tuberculosis: The role of social determinants

ODONE, Anna;
2016-01-01

Abstract

Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance. It is important to identify factors associated with these different mechanisms to optimize control measures. We conducted a prospective cohort study of index TB patients and their household contacts in Lima, Peru to identify risk factors associated with acquired and transmitted resistance, respectively. Patients with higher socioeconomic status (SES) had a 3-fold increased risk of transmitted resistance compared to those with lower SES when acquired resistance served as the baseline. Quality of housing mediated most of the impact of SES.
2016
Acquired and transmitted multidrug resistant tuberculosis: The role of social determinants / Odone, Anna; Calderon, Roger; Becerra, Mercedes C.; Zhang, Zibiao; Contreras, Carmen C.; Yataco, Rosa; Galea, Jerome; Lecca, Leonid; Bonds, Matthew H.; Mitnick, Carole D.; Murray, Megan B.. - In: PLOS ONE. - ISSN 1932-6203. - 11:1(2016), p. e0146642. [10.1371/journal.pone.0146642]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2822985
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