Perinatal exposure to endocrine disruptors: Sex, timing and behavioral endpoints

Of the approximately 85,000 chemicals in use, 1000 have been identified as having the ability to disrupt normal endocrine function. Exposure to endocrine disrupting chemicals (EDCs) during critical periods in brain differentiation (prenatal and neonatal life) via the mother can alter the course of the development of sexually dimorphic behaviors. Bisphenol A (BPA) is a very high volume chemical used in plastic, resins and other products, and virtually everyone examined has detectable BPA. BPA has estrogenic activity and is one of the most studied EDCs. We review evidence from studies in rodents using dose levels relevant to human exposure, BPA alter behavior and eliminates, and in some cases reverses, sexually dimorphic behaviors observed in unexposed animals.