NOC, NOC! Who's there? We have expanded the body of structure-activity relationships (SAR) regarding the 3-isoxazolecarboxylic acid ethyl esters by the design and synthesis of 5-aryl- and 5-[(N-aryl)amino]methyl analogues. Compounds were active against Mycobacterium tuberculosis (Mtb) at sub-micromolar concentrations and, for selected compounds, no toxicity was observed on Vero cells. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

NOC chemistry for tuberculosis - Further investigations on the structure-activity relationships of antitubercular isoxazole-3-carboxylic acid ester derivatives / Pieroni, Marco; Lilienkampf, Annamaria; Wang, Yuehong; Wan, Baojie; Cho, Sanghyun; Franzblau, Scott G.; Kozikowski, Alan P.. - In: CHEMMEDCHEM. - ISSN 1860-7179. - 5:10(2010), pp. 1667-1672. [10.1002/cmdc.201000169]

NOC chemistry for tuberculosis - Further investigations on the structure-activity relationships of antitubercular isoxazole-3-carboxylic acid ester derivatives

PIERONI, Marco;
2010-01-01

Abstract

NOC, NOC! Who's there? We have expanded the body of structure-activity relationships (SAR) regarding the 3-isoxazolecarboxylic acid ethyl esters by the design and synthesis of 5-aryl- and 5-[(N-aryl)amino]methyl analogues. Compounds were active against Mycobacterium tuberculosis (Mtb) at sub-micromolar concentrations and, for selected compounds, no toxicity was observed on Vero cells. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
2010
NOC chemistry for tuberculosis - Further investigations on the structure-activity relationships of antitubercular isoxazole-3-carboxylic acid ester derivatives / Pieroni, Marco; Lilienkampf, Annamaria; Wang, Yuehong; Wan, Baojie; Cho, Sanghyun; Franzblau, Scott G.; Kozikowski, Alan P.. - In: CHEMMEDCHEM. - ISSN 1860-7179. - 5:10(2010), pp. 1667-1672. [10.1002/cmdc.201000169]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2822817
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