We previously reported the discovery of diphenylimidazoles as potent sodium channel blockers, potentially useful in the treatment of epilepsy. To further understand the structural requirements for the potency of these derivatives, we have synthesized new compounds introducing a carbonyl moyety between the imidazole and the phenyl ring in the two position, then reducing it to alchool, and we have tested them for their NaV1.6 sodium channel blocking activity and in rodent acute seizures models.

Sodium Channel Blocking Activity and In-vivo Testing of New Phenyl-imidazole Derivatives / Rivara, Mirko; Patel, Manoj K.; Alberto, Rapalli; Zuliani, Valentina. - In: LETTERS IN DRUG DESIGN & DISCOVERY. - ISSN 1570-1808. - 13:9(2016), pp. 962-967. [10.2174/1570180813666160714125755]

Sodium Channel Blocking Activity and In-vivo Testing of New Phenyl-imidazole Derivatives.

RIVARA, Mirko;ZULIANI, Valentina
2016

Abstract

We previously reported the discovery of diphenylimidazoles as potent sodium channel blockers, potentially useful in the treatment of epilepsy. To further understand the structural requirements for the potency of these derivatives, we have synthesized new compounds introducing a carbonyl moyety between the imidazole and the phenyl ring in the two position, then reducing it to alchool, and we have tested them for their NaV1.6 sodium channel blocking activity and in rodent acute seizures models.
Sodium Channel Blocking Activity and In-vivo Testing of New Phenyl-imidazole Derivatives / Rivara, Mirko; Patel, Manoj K.; Alberto, Rapalli; Zuliani, Valentina. - In: LETTERS IN DRUG DESIGN & DISCOVERY. - ISSN 1570-1808. - 13:9(2016), pp. 962-967. [10.2174/1570180813666160714125755]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2816291
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