Purposes: The aim of this study was to evaluate whether sublobar resection could achieve recurrence and survival rates equivalent to lobectomy in high-risk elderly patients. Methods: We conducted a retrospective multicenter study that including all consecutive patients (aged >75 years) who underwent operation for clinical stage I non-small cell lung cancer (NSCLC). The clinicopathological data, postoperative morbidity and mortality, recurrence rate and vital status were retrieved. The overall survival, cancer-specific survival and disease-free survival were also assessed. Results: Two hundred and thirty-nine patients (median age 78 years) were enrolled. Lobectomies were performed in 149 (62.3 %) patients and sublobar resections in 90 (39 segmentectomies, 51 wedge resections). There were no differences in the recurrence rates following lobar versus sublobar resections (19 versus 23 %, respectively; p = 0.5) or the overall survival (p = 0.1), cancer-specific survival (p = 0.3) or disease-free survival (p = 0.1). After adjusting for 1:1 propensity score matching and a matched pair analysis, the results remained unchanged. A tumor size >2 cm and pN2 disease were independent negative prognostic factors in unmatched (p = 0.01 and p = 0.0003, respectively) and matched (p = 0.02 and p = 0.005, respectively) analyses. Conclusions: High-risk elderly patients may benefit from sublobar resection, which provides an equivalent long-term survival compared to lobectomy.

Sublobar resection versus lobectomy for stage I non-small cell lung cancer: an appropriate choice in elderly patients? / Fiorelli, Alfonso; Caronia, Francesco Paolo; Daddi, Niccolò; Loizzi, Domenico; Ampollini, Luca; Ardò, Nicoletta; Ventura, Luigi; Carbognani, Paolo; Potenza, Rossella; Ardissone, Francesco; Sollitto, Francesco; Mattioli, Sandro; Puma, Francesco; Santini, Mario; Ragusa, Mark. - In: SURGERY TODAY. - ISSN 0941-1291. - (2016), pp. 1-13. [10.1007/s00595-016-1314-8]

Sublobar resection versus lobectomy for stage I non-small cell lung cancer: an appropriate choice in elderly patients?

AMPOLLINI, Luca;VENTURA, LUIGI;CARBOGNANI, Paolo;
2016-01-01

Abstract

Purposes: The aim of this study was to evaluate whether sublobar resection could achieve recurrence and survival rates equivalent to lobectomy in high-risk elderly patients. Methods: We conducted a retrospective multicenter study that including all consecutive patients (aged >75 years) who underwent operation for clinical stage I non-small cell lung cancer (NSCLC). The clinicopathological data, postoperative morbidity and mortality, recurrence rate and vital status were retrieved. The overall survival, cancer-specific survival and disease-free survival were also assessed. Results: Two hundred and thirty-nine patients (median age 78 years) were enrolled. Lobectomies were performed in 149 (62.3 %) patients and sublobar resections in 90 (39 segmentectomies, 51 wedge resections). There were no differences in the recurrence rates following lobar versus sublobar resections (19 versus 23 %, respectively; p = 0.5) or the overall survival (p = 0.1), cancer-specific survival (p = 0.3) or disease-free survival (p = 0.1). After adjusting for 1:1 propensity score matching and a matched pair analysis, the results remained unchanged. A tumor size >2 cm and pN2 disease were independent negative prognostic factors in unmatched (p = 0.01 and p = 0.0003, respectively) and matched (p = 0.02 and p = 0.005, respectively) analyses. Conclusions: High-risk elderly patients may benefit from sublobar resection, which provides an equivalent long-term survival compared to lobectomy.
2016
Sublobar resection versus lobectomy for stage I non-small cell lung cancer: an appropriate choice in elderly patients? / Fiorelli, Alfonso; Caronia, Francesco Paolo; Daddi, Niccolò; Loizzi, Domenico; Ampollini, Luca; Ardò, Nicoletta; Ventura, Luigi; Carbognani, Paolo; Potenza, Rossella; Ardissone, Francesco; Sollitto, Francesco; Mattioli, Sandro; Puma, Francesco; Santini, Mario; Ragusa, Mark. - In: SURGERY TODAY. - ISSN 0941-1291. - (2016), pp. 1-13. [10.1007/s00595-016-1314-8]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2815205
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 62
  • ???jsp.display-item.citation.isi??? 60
social impact