We report on the synthesis and characterization of a composite nanostructure based on the coupling of cerium fluoride (CeF3) and zinc oxide (ZnO) for applications in self-lighted photodynamic therapy. Self-lighted photodynamic therapy is a novel approach for the treatment of deep cancers by low doses of X-rays. CeF3 is an efficient scintillator: when illuminated by X-rays it emits UV light by fluorescence at 325 nm. In this work, we simulate this effect by exciting directly CeF3 fluorescence by UV radiation. ZnO is photo-activated in cascade, to produce reactive oxygen species. This effect was recently demonstrated in a physical mixture of distinct nanoparticles of CeF3 and ZnO [Radiat. Meas. (2013) 59:139–143]. Oxide surface provides a platform for rational functionalization, e.g., by targeting molecules for specific tumors. Our composite nanostructure is stable in aqueous media with excellent optical coupling between the two components; we characterize its uptake and its good cell viability, with very low intrinsic cytotoxicity in dark.

CeF3-ZnO scintillating nanocomposite for self-lighted photodynamic therapy of cancer / Rimoldi, Tiziano; Orsi, Davide; Lagonegro, Paola; Ghezzi, Benedetta; Galli, Carlo; Rossi, Francesca; Salviati, Giancarlo; Cristofolini, Luigi. - In: JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE. - ISSN 0957-4530. - 27:10(2016), p. 159. [10.1007/s10856-016-5769-3]

CeF3-ZnO scintillating nanocomposite for self-lighted photodynamic therapy of cancer

RIMOLDI, Tiziano;ORSI, Davide;Ghezzi, Benedetta;GALLI, Carlo;SALVIATI, Giancarlo;CRISTOFOLINI, Luigi
2016

Abstract

We report on the synthesis and characterization of a composite nanostructure based on the coupling of cerium fluoride (CeF3) and zinc oxide (ZnO) for applications in self-lighted photodynamic therapy. Self-lighted photodynamic therapy is a novel approach for the treatment of deep cancers by low doses of X-rays. CeF3 is an efficient scintillator: when illuminated by X-rays it emits UV light by fluorescence at 325 nm. In this work, we simulate this effect by exciting directly CeF3 fluorescence by UV radiation. ZnO is photo-activated in cascade, to produce reactive oxygen species. This effect was recently demonstrated in a physical mixture of distinct nanoparticles of CeF3 and ZnO [Radiat. Meas. (2013) 59:139–143]. Oxide surface provides a platform for rational functionalization, e.g., by targeting molecules for specific tumors. Our composite nanostructure is stable in aqueous media with excellent optical coupling between the two components; we characterize its uptake and its good cell viability, with very low intrinsic cytotoxicity in dark.
CeF3-ZnO scintillating nanocomposite for self-lighted photodynamic therapy of cancer / Rimoldi, Tiziano; Orsi, Davide; Lagonegro, Paola; Ghezzi, Benedetta; Galli, Carlo; Rossi, Francesca; Salviati, Giancarlo; Cristofolini, Luigi. - In: JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE. - ISSN 0957-4530. - 27:10(2016), p. 159. [10.1007/s10856-016-5769-3]
File in questo prodotto:
File Dimensione Formato  
10856_2016_5769_Author.pdf

accesso aperto

Tipologia: Documento in Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 1.19 MB
Formato Adobe PDF
1.19 MB Adobe PDF Visualizza/Apri
EDITORS_CHOICE_JMSM_October+Editorial+Sept+21+2016+Final.pdf

accesso aperto

Descrizione: Editoriale della rivista per il mese di ottobre, basato sul nostro lavoro
Tipologia: Altro materiale allegato
Licenza: Creative commons
Dimensione 135.61 kB
Formato Adobe PDF
135.61 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2813443
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 15
  • ???jsp.display-item.citation.isi??? 14
social impact