We report the molecular cloning of the human laminin α3b chain variant and its mRNA expression pattern in adult human tissues when compared to the α3a variant. The mRNA encoding for the α3b variant is about 11 kb and the predicted translation product carries the complete set of domains typical for a 'full-sized' laminin α chain. Apart from the similar domain structure of α3b also the sequence of α3 resulted more closely related to the α5 than to the α4 chain. Quantitative analysis of the RNA expression in a broad panel of adult human tissues indicated that the α3b variant is more midely distributed than the α3a shorter variant.
the human α3b is a 'full-sized' laminin chain variant with a more widespread tissue expression than the truncated α3a / Doliana, Roberto; Bellina, Isabella; Bucciotti, Francesco; Mongiat, Maurizio; Perris, Roberto; Colombatti, Alfonso. - In: FEBS LETTERS. - ISSN 0014-5793. - 417:1(1997), pp. 65-70. [10.1016/S0014-5793(97)01251-9]
the human α3b is a 'full-sized' laminin chain variant with a more widespread tissue expression than the truncated α3a
PERRIS, Roberto;
1997-01-01
Abstract
We report the molecular cloning of the human laminin α3b chain variant and its mRNA expression pattern in adult human tissues when compared to the α3a variant. The mRNA encoding for the α3b variant is about 11 kb and the predicted translation product carries the complete set of domains typical for a 'full-sized' laminin α chain. Apart from the similar domain structure of α3b also the sequence of α3 resulted more closely related to the α5 than to the α4 chain. Quantitative analysis of the RNA expression in a broad panel of adult human tissues indicated that the α3b variant is more midely distributed than the α3a shorter variant.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
