Objective: We studied the impact of chlorinated agents exposure on exhaled breath condensate (EBC) biomarkers in cleaners. Methods: Malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), nitrites (NO-2 ), nitrates (NO-3 ), pH, hydrogen peroxide (H2O2) and ammonium (NH+3 ) were tested in EBC of 40 cleaners and 40 non-exposed controls. Pentraxin-3 (PTX3) and soluble type II receptor of IL-1 (sIL-1RII) were analyzed also in plasma. Results: Levels of MDA-EBC, 4-HNE-EBC and NO-3 -EBC were higher, while pH-EBC values were lower, in cleaners. MDA-EBC was associated with 4-HNE-EBC, NO-3 -EBC and pH. 4-HNE-EBC correlated with PTX3. Conclusion: Professional exposure to chlorinated agents increases EBC biomarkers of oxidative stress and inflammation.
Biomarkers of oxidative-stress and inflammation in exhaled breath condensate from hospital cleaners / Casimirri, Enrico; Stendardo, Mariarita; Bonci, Melissa; Andreoli, Roberta; Bottazzi, Barbara; Leone, Roberto; Schito, Michela; Vaccari, Alice; Papi, Alberto; Contoli, Marco; Corradi, Massimo; Boschetto, Piera. - In: BIOMARKERS. - ISSN 1354-750X. - 21:2(2016), pp. 115-122. [10.3109/1354750X.2015.1118541]
Biomarkers of oxidative-stress and inflammation in exhaled breath condensate from hospital cleaners
ANDREOLI, Roberta;LEONE, ROBERTO;CORRADI, Massimo;
2016-01-01
Abstract
Objective: We studied the impact of chlorinated agents exposure on exhaled breath condensate (EBC) biomarkers in cleaners. Methods: Malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), nitrites (NO-2 ), nitrates (NO-3 ), pH, hydrogen peroxide (H2O2) and ammonium (NH+3 ) were tested in EBC of 40 cleaners and 40 non-exposed controls. Pentraxin-3 (PTX3) and soluble type II receptor of IL-1 (sIL-1RII) were analyzed also in plasma. Results: Levels of MDA-EBC, 4-HNE-EBC and NO-3 -EBC were higher, while pH-EBC values were lower, in cleaners. MDA-EBC was associated with 4-HNE-EBC, NO-3 -EBC and pH. 4-HNE-EBC correlated with PTX3. Conclusion: Professional exposure to chlorinated agents increases EBC biomarkers of oxidative stress and inflammation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
