Objective: To identify predictors of 10-year Expanded Disability Status Scale (EDSS) change after treatment initiation in patients with relapse-onset multiple sclerosis. Methods: Using data obtained from MSBase, we defined baseline as the date of first injectable therapy initiation. Patients need only have remained on injectable therapy for 1 day and were monitored on any approved disease-modifying therapy, or no therapy thereafter. Median EDSS score changes over a 10-year period were determined. Predictors of EDSS change were then assessed using median quantile regression analysis. Sensitivity analyses were further performed. Results: We identified 2,466 patients followed up for at least 10 years reporting post-baseline disability scores. Patients were treated an average 83% of their follow-up time. EDSS scores increased by a median 1 point (interquartile range=0-2) at 10 years post-baseline. Annualized relapse rate was highly predictive of increases in median EDSS over 10 years (coeff=1.14, p=1.9×10-22). On-therapy relapses carried greater burden than off-therapy relapses. Cumulative treatment exposure was independently associated with lower EDSS at 10 years (coeff=-0.86, p=1.3×10-9). Furthermore, pregnancies were also independently associated with lower EDSS scores over the 10-year observation period (coeff=-0.36, p=0.009). Interpretation: We provide evidence of long-term treatment benefit in a large registry cohort, and provide evidence of long-term protective effects of pregnancy against disability accrual. We demonstrate that high annualized relapse rate, particularly on-treatment relapse, is an indicator of poor prognosis.

Predictors of long-term disability accrual in relapse-onset multiple sclerosis / Jokubaitis, Vilija G.; Spelman, Tim; Kalincik, Tomas; Lorscheider, Johannes; Havrdova, Eva; Horakova, Dana; Duquette, Pierre; Girard, Marc; Prat, Alexandre; Izquierdo, Guillermo; Grammond, Pierre; Van Pesch, Vincent; Pucci, Eugenio; Grand'Maison, François; Hupperts, Raymond; Granella, Franco; Sola, Patrizia; Bergamaschi, Roberto; Iuliano, Gerardo; Spitaleri, Daniele; Boz, Cavit; Hodgkinson, Suzanne; Olascoaga, Javier; Verheul, Freek; Mccombe, Pamela; Petersen, Thor; Rozsa, Csilla; Lechner Scott, Jeannette; Saladino, Maria Laura; Farina, Deborah; Iaffaldano, Pietro; Paolicelli, Damiano; Butzkueven, Helmut; Lugaresi, Alessandra; Trojano, Maria. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - 80:1(2016), pp. 89-100. [10.1002/ana.24682]

Predictors of long-term disability accrual in relapse-onset multiple sclerosis

GRANELLA, Franco;
2016-01-01

Abstract

Objective: To identify predictors of 10-year Expanded Disability Status Scale (EDSS) change after treatment initiation in patients with relapse-onset multiple sclerosis. Methods: Using data obtained from MSBase, we defined baseline as the date of first injectable therapy initiation. Patients need only have remained on injectable therapy for 1 day and were monitored on any approved disease-modifying therapy, or no therapy thereafter. Median EDSS score changes over a 10-year period were determined. Predictors of EDSS change were then assessed using median quantile regression analysis. Sensitivity analyses were further performed. Results: We identified 2,466 patients followed up for at least 10 years reporting post-baseline disability scores. Patients were treated an average 83% of their follow-up time. EDSS scores increased by a median 1 point (interquartile range=0-2) at 10 years post-baseline. Annualized relapse rate was highly predictive of increases in median EDSS over 10 years (coeff=1.14, p=1.9×10-22). On-therapy relapses carried greater burden than off-therapy relapses. Cumulative treatment exposure was independently associated with lower EDSS at 10 years (coeff=-0.86, p=1.3×10-9). Furthermore, pregnancies were also independently associated with lower EDSS scores over the 10-year observation period (coeff=-0.36, p=0.009). Interpretation: We provide evidence of long-term treatment benefit in a large registry cohort, and provide evidence of long-term protective effects of pregnancy against disability accrual. We demonstrate that high annualized relapse rate, particularly on-treatment relapse, is an indicator of poor prognosis.
2016
Predictors of long-term disability accrual in relapse-onset multiple sclerosis / Jokubaitis, Vilija G.; Spelman, Tim; Kalincik, Tomas; Lorscheider, Johannes; Havrdova, Eva; Horakova, Dana; Duquette, Pierre; Girard, Marc; Prat, Alexandre; Izquierdo, Guillermo; Grammond, Pierre; Van Pesch, Vincent; Pucci, Eugenio; Grand'Maison, François; Hupperts, Raymond; Granella, Franco; Sola, Patrizia; Bergamaschi, Roberto; Iuliano, Gerardo; Spitaleri, Daniele; Boz, Cavit; Hodgkinson, Suzanne; Olascoaga, Javier; Verheul, Freek; Mccombe, Pamela; Petersen, Thor; Rozsa, Csilla; Lechner Scott, Jeannette; Saladino, Maria Laura; Farina, Deborah; Iaffaldano, Pietro; Paolicelli, Damiano; Butzkueven, Helmut; Lugaresi, Alessandra; Trojano, Maria. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - 80:1(2016), pp. 89-100. [10.1002/ana.24682]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2810066
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