Purpose: To determine the relationship between lung cancer and emphysema by using high-precision 3D image analysis tools on volumetric thin-section CT data. Methods and Materials: Low-dose thin-section CT emphysema features of sub- jects with either symptomatic or screening-trial detected lung cancer (n = 124) were compared with those of 987 controls recruited by the same lung cancer screening trial. All CT scans were obtained according to the same protocol and analysed with a prototypical emphysema detection software (MeVis research), which provides a region-based assessment of the following parameters: lung volumes, mean lung density, emphysema index and four classes of emphysema clusters with different volumes. Multiple regression models were used to assess emphysema features as potential risk factor for lung cancer, after allowance for gender, age, body mass index (BMI), smoking history, forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC ratio. Results: We found no compelling evidence to suggest that any emphysema feature was associated with lung cancer. No differences in terms of emphysema phenotype were observed between subjects with screening-detected lung cancer and those with cancer detected outside the screening trial. The likelihood of lung cancer was signi cantly higher amongst those with air ow obstruction on spirometry (odds ratio = 0.91, 95% con dence interval [CI] 0.88-0.93). Conclusion: These results show an increased risk of lung cancer associated with airway obstruction. However, emphysema per se is not associated with an increased risk of lung cancer.

Relationship between lung cancer and pulmonary emphysema / Sverzellati, Nicola; Randi, Giorgia; Calabrò, Elisa; Silva, Mario; Kunhigk, Jan Martin; Marchianò, Alfonso; Zompatori, Maurizio; Pastorino, Ugo. - In: INSIGHTS INTO IMAGING. - ISSN 1869-4101. - 2:(2011), pp. 135-324-324. (Intervento presentato al convegno European Congress of Radiology tenutosi a Vienna (AT) nel March 3-6, 2011) [10.1007/s13244-011-0077-4].

Relationship between lung cancer and pulmonary emphysema

SVERZELLATI, Nicola;SILVA, Mario;
2011-01-01

Abstract

Purpose: To determine the relationship between lung cancer and emphysema by using high-precision 3D image analysis tools on volumetric thin-section CT data. Methods and Materials: Low-dose thin-section CT emphysema features of sub- jects with either symptomatic or screening-trial detected lung cancer (n = 124) were compared with those of 987 controls recruited by the same lung cancer screening trial. All CT scans were obtained according to the same protocol and analysed with a prototypical emphysema detection software (MeVis research), which provides a region-based assessment of the following parameters: lung volumes, mean lung density, emphysema index and four classes of emphysema clusters with different volumes. Multiple regression models were used to assess emphysema features as potential risk factor for lung cancer, after allowance for gender, age, body mass index (BMI), smoking history, forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC ratio. Results: We found no compelling evidence to suggest that any emphysema feature was associated with lung cancer. No differences in terms of emphysema phenotype were observed between subjects with screening-detected lung cancer and those with cancer detected outside the screening trial. The likelihood of lung cancer was signi cantly higher amongst those with air ow obstruction on spirometry (odds ratio = 0.91, 95% con dence interval [CI] 0.88-0.93). Conclusion: These results show an increased risk of lung cancer associated with airway obstruction. However, emphysema per se is not associated with an increased risk of lung cancer.
2011
Relationship between lung cancer and pulmonary emphysema / Sverzellati, Nicola; Randi, Giorgia; Calabrò, Elisa; Silva, Mario; Kunhigk, Jan Martin; Marchianò, Alfonso; Zompatori, Maurizio; Pastorino, Ugo. - In: INSIGHTS INTO IMAGING. - ISSN 1869-4101. - 2:(2011), pp. 135-324-324. (Intervento presentato al convegno European Congress of Radiology tenutosi a Vienna (AT) nel March 3-6, 2011) [10.1007/s13244-011-0077-4].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2809670
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