BACKGROUND AND OBJECTIVES: Anastomotic recurrence (AR), whose etiopathogenesis is attributed to intraluminal implantation of cancerous cells or metachronous carcinogenesis, is a major issue for patients undergoing colon cancer (CC) resection. The objective of the study is to throw some light on AR etiopathogenesis and to identify risk factors of AR in selecting patients to undergo early endoscopy. METHODS: An analysis of clinical and histopathological parameters, including MSI and LOH of seven sites (Myc-L, BAT26, BAT40, D5S346, D18S452, D18S64, D16S402) was performed in primary CC and AR of 18 patients. They were then compared to 36 controls not developing AR. RESULTS: A genetic instability was present in 16/18 patients, with distinct genetic patterns between primaries and ARs. LOH at 5q21 and/or 18p11.23 were found in both primary and AR in >50% of cases, but this rate was no different from control population. CEA resulted as associated with AR (P = 0.03), whereas N status presented a borderline result (P = 0.08). CONCLUSIONS: Our findings challenge present theories about AR development. No "genetic marker" has been found. CEA and, to a lesser extent, N status, appear associated with AR. Rectal washout is seemingly meaningless. Iterative resection should be recommended since a long survival may be expected. J. Surg. Oncol. 2016;114:228-236. © 2016 Wiley Periodicals, Inc.

ANASTOMOTIC RECURRENCE OF COLON CANCER: GENETIC ANALYSIS CHALLANGES THE WIDELY HELD THEORIES OF CANCEROUS CELLS’ INTRALUMINAL IMPLANTATION AND METACHRONOUS CARCINOGENESIS / Costi, R; Santi, C; Bottarelli, L; Azzoni, C; Zarzavadjian le Bian, A; Riccò, M; Sarli, L; Silini, Em; Violi, V.. - In: JOURNAL OF SURGICAL ONCOLOGY.SUPPLEMENT. - ISSN 1046-7416. - 114:2(2016), pp. 228-236. [10.1002/jso.24282]

ANASTOMOTIC RECURRENCE OF COLON CANCER: GENETIC ANALYSIS CHALLANGES THE WIDELY HELD THEORIES OF CANCEROUS CELLS’ INTRALUMINAL IMPLANTATION AND METACHRONOUS CARCINOGENESIS

COSTI, Renato;SANTI, Caterina;BOTTARELLI, Lorena;AZZONI, Cinzia;RICCO', Matteo;SARLI, Leopoldo;SILINI, Enrico Maria;VIOLI, Vincenzo
2016

Abstract

BACKGROUND AND OBJECTIVES: Anastomotic recurrence (AR), whose etiopathogenesis is attributed to intraluminal implantation of cancerous cells or metachronous carcinogenesis, is a major issue for patients undergoing colon cancer (CC) resection. The objective of the study is to throw some light on AR etiopathogenesis and to identify risk factors of AR in selecting patients to undergo early endoscopy. METHODS: An analysis of clinical and histopathological parameters, including MSI and LOH of seven sites (Myc-L, BAT26, BAT40, D5S346, D18S452, D18S64, D16S402) was performed in primary CC and AR of 18 patients. They were then compared to 36 controls not developing AR. RESULTS: A genetic instability was present in 16/18 patients, with distinct genetic patterns between primaries and ARs. LOH at 5q21 and/or 18p11.23 were found in both primary and AR in >50% of cases, but this rate was no different from control population. CEA resulted as associated with AR (P = 0.03), whereas N status presented a borderline result (P = 0.08). CONCLUSIONS: Our findings challenge present theories about AR development. No "genetic marker" has been found. CEA and, to a lesser extent, N status, appear associated with AR. Rectal washout is seemingly meaningless. Iterative resection should be recommended since a long survival may be expected. J. Surg. Oncol. 2016;114:228-236. © 2016 Wiley Periodicals, Inc.
ANASTOMOTIC RECURRENCE OF COLON CANCER: GENETIC ANALYSIS CHALLANGES THE WIDELY HELD THEORIES OF CANCEROUS CELLS’ INTRALUMINAL IMPLANTATION AND METACHRONOUS CARCINOGENESIS / Costi, R; Santi, C; Bottarelli, L; Azzoni, C; Zarzavadjian le Bian, A; Riccò, M; Sarli, L; Silini, Em; Violi, V.. - In: JOURNAL OF SURGICAL ONCOLOGY.SUPPLEMENT. - ISSN 1046-7416. - 114:2(2016), pp. 228-236. [10.1002/jso.24282]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2808559
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