In the present work we report an investigation on cultures of the human osteosarcoma cell line «MG-63» and the human osteoblastic cell line «HOBIT». We have examined the combined effects of hematin and 14.4keV gamma-radiation from a Mössbauer source. Preliminary results seem to confirm the trend already observed for the bone marrow system. Different degrees of growth inhibition were observed when hematin alone and hematin plus gamma-rays were administered to the cultures. It was previously found that hematin has no toxic effects on normal cells up to a concentration of 10-4 M, but the same concentration produces various degrees of inhibition on cultures of tumor cells. While no significant effect could be attributed to irradiation alone, hematin plus irradiations show a larger inhibition than that expected for pure additive effects. © 1996 Società Italiana di Fisica.

Effects of hematin and Mössbauer gamma-radiation on human osteosarcoma cell lines / Ortalli, Ida; Pedrazzi, Giuseppe; Fano, Vincenzo; Ma, W. Y.; Cai, S. Z.; Giuliani, Nicola; Passeri, Mario. - In: NUOVO CIMENTO DELLA SOCIETÀ ITALIANA DI FISICA. D CONDENSED MATTER, ATOMIC, MOLECULAR AND CHEMICAL PHYSICS, BIOPHYSICS. - ISSN 0392-6737. - 18:2-3(1996), pp. 359-363. [10.1007/BF02458918]

Effects of hematin and Mössbauer gamma-radiation on human osteosarcoma cell lines

ORTALLI, Ida;PEDRAZZI, Giuseppe;FANO, Vincenzo;GIULIANI, Nicola;PASSERI, Mario
1996

Abstract

In the present work we report an investigation on cultures of the human osteosarcoma cell line «MG-63» and the human osteoblastic cell line «HOBIT». We have examined the combined effects of hematin and 14.4keV gamma-radiation from a Mössbauer source. Preliminary results seem to confirm the trend already observed for the bone marrow system. Different degrees of growth inhibition were observed when hematin alone and hematin plus gamma-rays were administered to the cultures. It was previously found that hematin has no toxic effects on normal cells up to a concentration of 10-4 M, but the same concentration produces various degrees of inhibition on cultures of tumor cells. While no significant effect could be attributed to irradiation alone, hematin plus irradiations show a larger inhibition than that expected for pure additive effects. © 1996 Società Italiana di Fisica.
Effects of hematin and Mössbauer gamma-radiation on human osteosarcoma cell lines / Ortalli, Ida; Pedrazzi, Giuseppe; Fano, Vincenzo; Ma, W. Y.; Cai, S. Z.; Giuliani, Nicola; Passeri, Mario. - In: NUOVO CIMENTO DELLA SOCIETÀ ITALIANA DI FISICA. D CONDENSED MATTER, ATOMIC, MOLECULAR AND CHEMICAL PHYSICS, BIOPHYSICS. - ISSN 0392-6737. - 18:2-3(1996), pp. 359-363. [10.1007/BF02458918]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2808290
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